Developmental neurobiology group-GNDe

Research

Team

PhD students
Carolina Melero Jerez
Sonia Nocera (I)
Technicians
Mario Lozano Enguita
Others
Pablo Sosa (graduate student, Univ. de Alcalá de Henares, Spain)

Past lab members

Dr. Diego Clemente López (postdoctoral researcher); current position: PI of the GNID, Hospital Nacional de Parapléjicos-SESCAM, Toledo, Spain.  

Dr. Ana Bribián Arruego (Ph. D student & Ph.D., postdoc); current position: senior postdoc at the Instituto Cajal-CSIC, Madrid, Spain

Dr. Diego García-González (Ph.D. student); current position: postdoctoral researcher at the German Cancer Institute, Heidelberg, Germany. 

Dr. Verónica Murcia-Belmonte (Ph.D. student); current position: postdoctoral researcher at the Instituto de Neurociencias/UMH-CSIC, Alicante, Spain

Dr. Eva-M. Medina-Rodríguez (Ph.D. student); current position: postdoctoral researcher at the University of Miami, Miami, USA  

Dr. Cristina Ortega Muñoz (Ph.D. and postdoc; current position: postdoctoral researcher at CBM-UAM/CSIC, Cantoblanco (Madrid), Spain

Dr. Paloma Merchán (Ph.D. student); current position: postdoctoral researcher at the Cincinnati Children´s Hospital, Cincinnati, USA

  Dr. Virginia Vila del Sol (postdoctoral researcher); current position: Chief of the Servicio de Citometría, Hospital Nacional de Parapléjicos, Toledo, Spain

 F. Javier Arenzana (Ph.D., postdoc)   

 Dr. Verónica Moliné-Velázquez (Ph.D student); current institution: Universidad de Granada

Dr. Pedro F. Esteban Ruiz (postdoctoral researcher); current position: postdoctoral fellow at Hospital Nacional de Parapléjicos, Toledo, Spain

Publications

• Medina-Rodríguez EM*, Bribián A*, Boyd A, Pastor J, Lagares A, Gil C, Martínez A, Williams A, & de Castro F (2017) New small phosphodiesterase 7 blockers effectively promote remyelination in vivo and open new neuroreparative strategies for clinical use in Multiple Sclerosis. Sci. Rep. 7, 43545 (doi: 10.1038/srep43545).
• Leonetti C, Macrez R, Pruvost M, Bronsard J, Fournier A, Perrigault M, Vivien D, Clemente D, de Castro F, Maubert E*, & Docagne F* (2017) Tissue plasminogen activator exerts chemokinetic effects on oligodendrocytes in white matter (re)myelination. Molecular Neurodegeneration 12:20 (DOI: 10.1186/s13024-017-0160-5).
• Pintado-Sierra, M., García-Álvarez, I., Bribián, A., Medina-Rodríguez, E.M., Lebrón-Aguilar, R., Garrido, L., de Castro, F., Fernández-Mayoralas, A., & Quintanilla-López, J.E. (2017) A comprehensive profiling of sulfatides in myelin from mouse brain using liquid chromatography-tandem mass spectrometry and high resolution accurate mass spectrometry. Analyt. Chim. Acta 951, 89-98.
• Marín-Bañasco, C., Benabdellah, K., Melero-Jerez, C., Oliver, B., Pinto-Medel, M.J., Hurtado-Guerrero, I., de Castro, F., Clemente, D., Fernández, Ó., Martin, F., Leyva, L., & Suardíaz-García, M. (2017) Gene therapy with mesenchymal stem cells expressing IFNß ameliorates neuroinflammation in experimental models of Multiple Sclerosis. Br. J. Pharmacol. 174, 238-253 (doi: 10.1111/bph.13674).
• de Castro, F. (2017) Human adult Oligodendrocyte Precursor Cell biology: the bottleneck for effective pro-remyelinating therapies for Multiple Sclerosis. In: Converging Clinical and Engineering Research on Neurorehabilitation (Editors: J.L. Pons & XXX) Springer International Publishing. Vol. II, 67-68.
• de Castro, F., Seal, R., y Maggi, R. (2016) ANOS1: a unified nomenclature for Kallmann syndrome 1 gene (KAL1) and anosmin-1. Brief. Funct. Genom. (In Press, BFGP-16-0031).
  de Castro, F., & Merchán, M.A. (2016) Editorial: The major discoveries of Cajal and his disciples: Consolidated milestones for the Neuroscience of the XXIst century. Front. Neuroanat. 10:85 (doi: 10.3389/fnana.2016.00085).
• Suardíaz, M., Clemente, D., Marín-Bañasco, C., Orpez, T., Guerrero-Hurtado, I., Pavía, P., Pinto-Medel, M.J., de Castro, F., Leyva, L., Fernández, Ó, & Oliver, B. (2016) Recombinant soluble IFN receptor (sIFNAR2) exhibits intrinsic therapeutic efficacy in a murine model of Multiple Sclerosis. Neuropharmacology 110, 480-492. (doi: 10.1016/j.neuropharm.2016.07.026).
• Sierra A, de Castro F, del Río-Hortega J, Iglesias-Rozas J, Garrosa M, & Kettenmann H (2016) The `big-bang´ for modern glial biology: translation and comments on Pío del Río-Hortega 1919 series of papers on microglia. Glia, 64:1801–1840 (doi:10.1002/glia.23046). “Cover page” selected for Volume 64 (Issue 11, pages 1795–2040). Recommended in F1000Prime as being of special significance in its field (http://f1000.com/prime/726748849?bd=1).
• Macrez*, R., Ortega*, M.C., Bardou, I., Mehra, A., Fournier, A., Van der Pol, S.M.A., Haelewyn, B., Maubert, E., Lesept, F., Chevilley, A., de Castro, F., De Vries, H.E., Vivien, D., Clemente*, D., & Docagne*, F. (2016) Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis. Brain 139; 2406–2419 (doi: http://dx.doi.org/10.1093/brain/aww172).
• de Castro, F. (2016) The Cajal School in the peripheral nervous system: the transcendent contributions of Fernando de Castro on the microscopic structure of sensory and autonomic motor ganglia. Front. Neuroanat. 10:43 (1-11) (doi: 10.3389/fnana.2016.00043).
• de Castro, F., & López-Mascaraque, L. (2016) Olfactory system embryonic development. In: Kaufman’s Atlas of Mouse Development Supplement: With Coronal Sections (ISBN: 978-0-12-800043-4; editors: R. Baldock, J. Bard, D.C. Davidson & G. Morriss-Kay). Pp. 286-292. Academic Press-Elsevier, USA/UK (doi: http://dx.doi.org/10.1016/B978-0-12-800043-4.00022-1).
• García-González, D., Murcia-Belmonte, M., Esteban, P.F., Ortega, F., Díaz, D., Sánchez-Vera, I., Lebrón-Galán, R., Escobar-Castañondo, L., Martínez-Millán, L., Weruaga, E., García-Verdugo, J.M., Berninger, B., & de Castro, F. (2016) Anosmin-1 over-expression increases adult neurogenesis in the subventricular zone and neuroblast migration to the olfactory bulb. Brain Struct. Funct. 221(1):239–260. (doi 10.1007/s00429-014-0904-8; PMID: 25300351).
• Murcia-Belmonte V., Esteban P.F., Martínez-Hernández J., Gruart A., Luján R., Delgado-García J.M., & de Castro F. (2016) Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness. Brain Struc. Funct. 221, 1365-1385 (doi 10.1007/s00429-014-0977-4; PMID: 25662897).
• Moliné-Velázquez, V., Vila-del Sol, V., de Castro, F., & Clemente, D. (2016) Myeloid cell distribution and activity in mutiple sclerosis. Histol. Histopathol. 31, 357-370 (DOI: 10.14670/HH-11-699).
• Merchán, M.A., DeFelipe, J., & de Castro, F. editores (2016) “Cajal and De Castro´s Neurohistological Methods”. Oxford University Press, Oxford (Gran Bretaña). ISBN 978-0-19-022159-1, 252 pages.
• Gutiérrez-Franco, A., Costa, C., Eixarch, H., Castillo, M., Medina-Rodríguez, E.M., Bribián, A., de Castro, F., Montalbán, X., & Espejo, C. (2016) Differential expression of sema3A and sema7A in a murine model of multiple sclerosis: implications for a therapeutic design. Clin. Immunol. 163, 22–33 (doi:10.1016/j.clim.2015.12.005).
• Murcia-Belmonte V., Esteban P.F., Martínez-Hernández J., Gruart A., Luján R., Delgado-García J.M., & de Castro F. (2016) Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness. Brain Struc. Funct. 221, 1365-1385 (doi 10.1007/s00429-014-0977-4; PMID: 25662897).
• García-González, D., Murcia-Belmonte, M., Esteban, P.F., Ortega, F., Díaz, D., Sánchez-Vera, I., Lebrón-Galán, R., Escobar-Castañondo, L., Martínez-Millán, L., Weruaga, E., García-Verdugo, J.M., Berninger, B., & de Castro, F. (2016) Anosmin-1 over-expression increases adult neurogenesis in the subventricular zone and neuroblast migration to the olfactory bulb. Brain Struct. Funct. 221(1):239–260. (doi 10.1007/s00429-014-0904-8; PMID: 25300351).
• Cases, O., Joseph, A., Obry, A., Santin, M.D., Pâques, M., Ben-Yacoub, S., Amsellem, S., Bribián, A., Simonutti, M., Augustin, S., Debeir, T., Sahel, J.-A., Christ, A., de Castro, F., Lehéricy, S., Cosette, P., and Kozyraki, R. (2015). Foxg1-cre mediated Lrp2 inactivation in the developing mouse neural retina, ciliary and retinal pigment epithelia models congenital high myopia. PLOS ONE In Press (PONE-D-14-55738R2).

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