LABORATORIES

Molecular bases of memory and neurodegeneration

Molecular bases of memory and neurodegeneration

Research

Staff

Publications

Contact

Others

Research

The general interest of our laboratory is twofold: on the one hand, to understand the internal functioning of proteins (one of the great pending subjects of Biology) and on the other hand, to explore possible biomedical and biotechnological applications of the knowledge acquired through our investigations.

Specifically, we are studying the molecular bases of memory and neurodegeneration. For this we have focused on amyloid proteins, both pathological (particularly neurotoxic proteins, involved in neurodegenerative diseases) as functional (neuronal CPB, a prionid involved in the consolidation of memory through active synapses marking).

Group website: https://carrionvazquezlab.cajal.csic.es/ 

Lines of investigation

1. Consolidation of memory and neurodegeneration

➤ CPEB3 and CPEB2: Structure/function relationships.

➤ CPEB3/CPEB2-MIELINIZATION RELATIONS.

➤ CPEB2 prionoid as probable epigenetic mediator of the transgenerational procedural inheritance.

➤ Path / functional hybrid interactions and amyloids: Kidnapping of functional amyloids (CPEB family) by neurotoxic proteins (Polyqs, Aβ, TDP-43).

    2. Biomedical and biotechnological applications

    ➤ QBP1 anti-amyloidogenic peptide as a leading drug for prevention/treatment (non-regulatory preclinical studies) of:

    ➜ Post -traumatic stress disorder (PTSP).

    ➜ Type 2 diabetes (DM2) and Alzheimer’s disease (EA) associated.

    ➜ Amyotrophic lateral sclerosis (ELA).

    ➤ Biotechnological developments:

    ➜ Protein nanotramp for pathogens based on the separation of CPEB phases.

    ➜ Enzymatic activity potentiator: Linker Q/N/W of a Ruminococus flavefaciens (Linker Xyna) xilasa.

    Staff

    Mariano Carrión Vázquez

    Principal investigator

    Mª Eugenia Vaquero Morales 

    Postdoctoral researcher

    Elena Anaya Cubero

    Predoctoral researcher

    María del Mar Tejero Ojeda

    Predoctoral researcher

    Paula López García

    Predoctoral researcher

    Ada Bernaus Vives

    Predoctoral researcher

    Wilmer Alfonso Pardo

    Postdoctoral researcher

    Andrea Collazo González

    Lab Manager | Technician

    Publications

    Publications of the last 10 years

    • Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization, Structure (2021), Vol. 29, Issue 6, PP. 587-597. Vera, A., Galera-Prat, A., Wojciechowski, M., Rozycki, B., Laurents, D.V., Carrión-Vázquez, M. and Tinnefeld, P. DOI: 10.1016/j.str.2021.01.006
    • Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold. BMC Biology (2021), Issue 19, Article number: 43. Hervás, R., Fernández-Ramírez, M.C., Galera-Prat, A., Suzuki, M., Nagai, Y., Bruix, M., Menéndez, M., Laurents, D.V., and Carrión-Vázquez, M. DOI: 10.1186/s12915-021-00967-9
    • Tau amyloidogenesis begins with a loss of its conformational polymorphism. bioRxiv (2020). Fernández-Ramírez, M.C., Hervás, R., Menéndez, M., Laurents, D.V. and Carrión-Vázquez M. DOI: 10.1101/2020.06.18.158923.
    • An anti-amyloidogenic treatment to specifically block the consolidation of traumatic events in mouse
      bioRxiv (2020).  López-García, P., Ramírez de Mingo, D., McGreevy, K.R., Santi, A., Laurents D.V., Nagai, Y., Trejo, J.L., and Carrión-Vázquez M. DOI: 10.1101/2020.06.18.158923
    • Preferred conformations in the intrinsically disordered region of human CPEB3 explain its role in memory consolidation
      bioRxiv (2020). Ramírez de Mingo D., Hervás, R., Pantoja-Uceda D., Carrión-Vázquez M., and Laurents D.V. DOI: 10.1101/2020.05.12.091587
    • Molecular determinants of liquid demixing and amyloidogenesis in human CPEB3. bioRxiv (2020). Ramírez de Mingo D., López-García, P., Hervás, R., Laurents D.V., and Carrión-Vázquez M. DOI: 10.1101/2020.06.02.129783
    • Impact of scaffoldin mechanostability on cellulosomal activity
      Biomat. Sci. (2020), Vol. 8, Issue 13, PP. 3601-3610. Portada de la revista. Galera-Prat, A., Vera, A.M., Moraïs, S. Vazana, Y., Bayer, E.A. and Carrión-Vázquez, M. DOI: 10.1039/C9BM02052G
    • Molecular mechanism of the inhibition of TDP-43 amyloidogenesis by QBP1. Arch. Biochem. Biophys. (2019), Vol. 675, PP. 108113.  Mompeán M., Ramírez de Mingo D., Hervás R., Fernández-Ramírez MDC, Carrión-Vázquez M., and Laurents D.V. DOI: 10.1016/j.abb.2019.108113
    • Resurrection of efficient Precambrian endoglucanases for lignocellulosic biomass hydrolysis. Communications Chemistry (2019), Issue 2, Article number: 76.  Barruetabeña, N. Alonso-Lerma, B. Galera-Prat, A. Joudeh, N., Barandiaran, L., Aldazábal, l., García-Parra, P. Marie Fertin, P., Manteca, A. Rodríguez-Couto, S., Arbulu, M., De Sancho, D., Alcalde, M., Carrión-Vázquez, M. & Pérez-Jiménez, R. DOI: 10.1038/s42004-019-0176-6.
    • Nanomechanics of tip-link cadherins. Sci. Rep. (2019), Issue 9, Article number: 13306. Oroz J., Galera-Prat A., Hervás R., Valbuena A., Fernández-Bravo D.,
      Carrión-Vázquez M. DOI: 10.1038/s41598-019-49518-x
    • Efficient and simplified nanomechanical analysis of intrinsically disordered proteins. Nanoscale (2018), Issue 10, PP. 16857–16867. Fernández-Ramírez, M.C., Hervás R., Galera-Prat A., Laurents D.V and Carrión-Vázquez M. DOI: 10.1039/c8nr02785d
    • The cohesin module is a major determinant of cellulosome mechanical stability. J Biol Chem. (2018), Vol. 293, Issue 19, PP. 7139-7147. Galera-Prat A, Moraïs S, Vazana Y, Bayer EA, Carrión-Vázquez M. DOI: 10.1074/jbc.RA117.000644
    • Solution conformation of a cohesin module and its scaffoldin linker from a prototypical cellulosome. Arch. Biochem. Biophys. (2018), Vol. 644, PP. 1-7. Galera-Prat A, Pantoja-Uceda D, Laurents DV, Carrión-Vázquez M. DOI: 10.1016/j.abb.2018.02.016
    • Non-local effects of point mutations on the stability of a protein module. J. Chem. Phys. (2017), Vol. 147, Issue 10, PP. 10.1063-1.4999703. Chwastyk M, Vera AM, Galera-Prat A, Gunnoo M, Thompson D, Carrión-Vázquez M., Cieplak M. DOI: 10.1063/1.4999703
    • Direct identification of protein-protein interactions in single-molecule force spectroscopy. Angew. Chem. (2016), Vol. 55, Issue 45, PP. 13970-13973. Vera, A. and Carrión-Vázquez M. DOI: 10.1002/anie.201605284
    • Unfolding knots by proteasome-like systems: simulations of the behaviour of folded and neurotoxic proteins. Mol. Biosyst. (2016), Vol. 12, Issue 9, PP. 2700-2712. Wojciechowski, M. Gómez-Sicilia, À., Carrión-Vázquez M. & Cieplak, M. DOI: 10.1039/C6MB00214E
    • The titin Y9P variant of the titin I27 module: structural determinants of its revisited nanomechanics. Structure (2016), Vol. 24, Issue 4, PP. 606-616. Oroz, J., Bruix, M. Laurents, D., Galera-Prat, A., Schönfelder, J., Cañada, F.J., and Carrión-Vázquez M. DOI: 10.1016/j.str.2016.02.016
    • Molecular basis of Orb2 amyloidogenesis and blockade of memory consolidation. PLOS Biol. (2016), Vol. 14, Issue 1, PP. e1002361. Hervás, R., Li, L., Majundar, A., Fernández-Ramírez, M.C., Unruh, J.R., Slaughter, B.D., Galera-Prat, A., Santana, E., Suzuki, M., Nagai, Y., Bruix, M., Casas-Tintó, S., Menéndez, M., Laurents, D.V., Si, K., and Carrión-Vázquez M. DOI: 10.1371/journal.pbio.1002361
    • Nano-scale engineering of designer cellulosomes. Adv. Mater. (2016), Vol. 28, Issue 27, PP. 5619-5647. Gunnoo. M., Cazade, P.-A., Galera-Prat, A., Nash, M.A., Czjzek, M., Cieplak, M., Alvarez, B., Aguiar, M., Karpol, A., Gaub, H., Carrión-Vázquez M., Bayer, E.A., & Thompson, D. DOI: 10.1002/adma.201503948
    • An exploration of the universe of polyglutamine structures. PLOS Comp. Biol. (2015), Vol. 11, Issue 10, PP. e1004541. Gómez-Sicilia, A., Sikora, M., Cieplak, M. and Carrión-Vázquez M. DOI: 10.1371/journal.pcbi.1004541.
    • Transcytosis in the blood-cerebrospinal fluid barrier of the mouse brain with an engineered receptor/ligand system. Mol Ther Methods Clin Dev. (2015), Vol. 2, PP. 15037. Méndez-Gómez, H.R., Galera-Prat, A., Meyers, C., Chen W, Carrión-Vázquez M.
      and Muzyczka, N. DOI: 10.1038/mtm.2015.37
    • Structural evidence of Amyloid Fibril Formation in the putative aggregation domain of TDP-43. J. Chem. Phys. Lett (2015), Vol. 6, Issue 13, PP. 2608–2615. Mompeán, M., Hervás, R., Xu, Y., Tran, T., Guarnaccia, C., Buratti, E., Baralle, F.,Tong, L., Carrión-Vázquez M., McDermott, A. & Laurents, D.V. DOI: 10.1021/acs.jpclett.5b00918
    • NMR spectroscopy reveals that polyglutamine binding peptide 1 adopts a preferred conformation with a defined hydrophobic cluster. Arch. Biochem. Biophys. (2014), Vol. 558, PP. 104-110
      Ramos-Martín, F., Hervás, R., Carrión-Vázquez M. & Laurents, D.V. DOI: 10.1016/j.abb.2014.06.025
    • Protein Unfolding by Biological Unfoldases: Insights from Modeling. Biophys. J. (2014), Vol. 107, Issue 7, PP. 1661-1668
      Wojciechowski, M., Szymczak, P., Carrión-Vázquez M. & Cieplak, M. DOI: 10.1016/j.bpj.2014.07.035
    • Imaging biological samples with atomic force microscopy. Cold Spring Harb. Protoc. (2014). de Pablo P.J. and Carrión-Vázquez M. DOI: 10.1101/pdb.top080473
    • Theoretical tests of the mechanical protection strategy in protein nanomechanics. Proteins (2014), Vol. 82, Issue 5, PP. 717
      Chwastyk, M., Galera–Prat, A., Sikora, M., Gómez-Sicilia, À., Carrión-Vázquez M. and Cieplak, M. DOI: 10.1002/prot.24436

    Contact

    Where to find us

    Carrión-Vázquez Lab

    Instituto Cajal CSIC. Avda. Doctor Arce, 37. 28002. Madrid

    Call us

    Phone:

    +34 915 854 750

    Write a message

    Email:

    mcarrion@cajal.csic.es

    Others 

    Doctoral Thesis

    • CPEB3 Human Prison Structure Relationship in memory consolidation. Daniel Ramírez de Mingo. Autonomous University of Madrid. 2020 (November 20). Outstanding Cl

    • Nanomechanics of the Tau monomer and development of a new strategy for its study. María del Carmen Fernández Ramírez. Autonomous University of Madrid. 2019 (May 10) Outstanding CL
      Nanomechanics of cellulosome: Implications for system activity. Albert Galera Prat. Autonomous University of Madrid. 2016 (February 5) Outstanding CL

    • The Universe of Neurotoxic Proteins: A Study of the Conformational Space of Polyglutamine and β – Amyloid. Ángel Manuel Gómez Sicilia. Autonomous University of Madrid. 2015 (October 15). European doctorate. OUTSTANDING

    • Nanomechanics of β-catenin and protein-protein interactions. Andrés Manuel Vera Gómez. Sevilla University. 2015 (May 22). Outstanding Cl

    • Neurotoxic protein nanomechanics: common molecular characteristics at the beginning of the neurodegeneration waterfall. Rubén Hervás Millán. Autonomous University of Madrid. 2013 (March 16). Outstanding Cl

    Master´s final works

    • Nanomecánica de la región amiloidogénica del prionoide funcional hCPEB3. Nora Serrano Bengoechea. Tesis del Máster en Neurociencia. Facultad de Ciencias Biológicas. Universidad Complutense de Madrid. Director y tutor. 11 de julio de 2019. SOBRESALIENTE 9.8
    • The nanomechanics of the amyloidogenic core of TDP-43. Sofía Bauzá de Mirabó Vidal. Tesis del Máster en Biotecnología. Facultad de Ciencias. Universidad Autónoma de Madrid. Director y tutor. 27 de junio de 2019. SOBRESALIENTE 8.5
    • Efecto del péptido anti-amiloidogénico QBP1 sobre la proteína CPEB3 implicada en la consolidación de la memoria: Posibles aplicaciones en la profilaxis y terapia del trastorno de estrés postraumático. Paula López García. Tesis del Máster en Neurociencia. Universidad Autónoma de Madrid. Director y tutor. 12 de marzo de 2018 SOBRESALIENTE. PREMIO ARQUÍMEDES
    • Study of an ancestral exocellulase and its incorporation into a designer cellulosome. Gonzalo Sáez García. Tesis del Máster en Biotecnología. Universidad Autónoma de Madrid. Director y tutor. 28 de junio de 2017. SOBRESALIENTE 9.8
    • Improving the mechanical stability of cohesin modules from scaffoldin. Alla Vernaya. Tesis del Máster en Biotecnología. Universidad Autónoma de Madrid. Director y tutor. 28 de junio de 2017. SOBRESALIENTE 9.8
    • Incorporation of a resurrected endocellulase into a designer cellulosome: comparison with natural cellulosomal endocellulases. Nadeem Joudeh. Tesis del Máster en Neurociencia. Universidad Autónoma de Madrid. Director y tutor. 20 de junio de 2016. SOBRESALIENTE
    • Nanomecánica de Mutantes Proagregantes de la Proteína Tau Asociados a FTDP-17. Roberto Carro Vázquez. Tesis del Máster en Neurociencia. Universidad Autónoma de Madrid. Director y tutor. 15 de marzo de 2016. SOBRESALIENTE
    • Estudio de la ruta amiloidogénica a través de la caracterización del polimorfismo conformacional del mutante E46K de α–sinucleína. Francisco Ramos Martín. Tesis del Máster en Neurociencia. Universidad Autónoma de Madrid. Director y tutor. 20 de marzo de 2013. SOBRESALIENTE
    • Efecto de los péptidos QBP1 y SV111 sobre la amiloidogéneses del β–amiloide. Laura Esther Abelleira Hervás. Tesis del Máster en Neurociencia. Universidad Autónoma de Madrid. Director y tutor. 20 de marzo de 2013. SOBRESALIENTE
    • La nanomecánica de la α-sinucleína E46K, asociada a parkinsonismo familiar severo. Clara Barrio García. Tesis del Máster en Biofísica. Universidad Autónoma de Madrid. Director y tutor. 4 de julio de 2012. SOBRESALIENTE
    • Estudio del polimorfismo conformacional de la proteína tau. María del Carmen Fernández Ramírez. Tesis del Máster en Neurociencia. Universidad Autónoma de Madrid.
      Director y tutor. 22 de marzo de 2012. SOBRESALIENTE
    • Regulación de la actividad sináptica mediada por cambios conformacionales. Elena Santana Martín. Tesis del Máster en Neurociencia. Universidad Autónoma de Madrid. Director y tutor. 22 de marzo de 2012. SOBRESALIENTE
    • La nanomecánica de las cadherinas auditivas y su modulación por calcio. Débora Fernández Bravo. Tesis del Máster en Neurociencia. Universidad Autónoma de Madrid. Director y tutor. 22 de marzo de 2012. SOBRESALIENTE

    Degree´s final works

    • Rastreo de candidatos proteicos para nanotrampa molecular contra patógenos en piscifactorías. Iván Fernández Muñoz. Universidad Politécnica de Madrid. Marzo de 2021. SOBRESALIENTE 9.4
    • Caracterización del polimorfismo conformacional de CPEB-3, una proteína prionoide funcional humana implicada en la consolidación de la memoria. Samanta Paz Recio. Universidad de Alcalá de Henares. 13 de julio de 2017. SOBRESALIENTE 9.6
    • Caracterización estructural y propiedades amiloidogénicas del Orb2, un prionoide implicado en consolidación de memoria. Elena Sevilla Alonso. Universidad de Alcalá de Henares. Julio de 2014. SOBRESALIENTE
    • Análisis molecular de la vía amloidogénica de CPEB, un prionoide implicado en consolidación de memoria. María del Cerro Moreno. Universidad de Alcalá de Henares. Julio de 2014. SOBRESALIENTE
    • Análisis de la melatonina como bloqueante de la cascada amiloidogénica del β–amiloide. Carmen del Sol Pascual. Universidad de Alcalá de Henares. Julio de 2013. SOBRESALIENTE
    • Efecto del péptido LPFFD sobre la amiloidogénesis del β–amiloide. María Luisa Franco Ribadeneira. Universidad de Alcalá de Henares. Julio de 2013. SOBRESALIENTE

    Monographs

    • Nanomechanics of amyloidogenic neurotoxic proteins: insights at the start of the neurodegeneration cascade. En: Uversky, V.N. & Lyubchenko, A.K. (Eds.) Bionanoimaging: Insights into Protein Misfolding and Aggregation (2014) Ed. Elsevier. Oxford. ISBN 978-0-12-394431-3. PP. 57-68. Hervás, R. Fernández-Ramírez, M.C., Abelleira L.E., Laurents, D.V. & Carrión-Vázquez, M.
    • Nanomechanics of proteins, both folded and disordered
      En: Oberhauser, A.F. (Ed.) Single-Molecule Studies of Proteins (2013) Ed. Springer-Verlag. Berlin, Heidelberg. ISBN 978-1-4614-4920-1. PP. 1-47. Hervás, R. Galera-Prat, A. Gómez-Sicilia, À. Losada-Urzáiz, F., Fernández, M.C., Fernández-Bravo, D., Santana, E., Barrio-García, C., Melero, C. & Carrión-Vázquez, M.
    • Unequivocal single-molecule force spectroscopy of intrinsically disordered proteins. En: Uversky, V.N. & A.K. Dunker (Eds.)
      Intrinsically Disordered Protein Analysis (2012) Ed. Springer Protocols. Humana Press. Springer-Verlag. Berlin, Heidelberg
      ISBN 978-1-4614-3703-1. PP. 71-87. Oroz, J., Hervás, R. Valbuena, A. & Carrión-Vázquez, M.
    • Single-molecule force spectroscopy. En: Reifenberger, R.G. & Baró, A. (Eds.) AFM in Liquids (2012) Ed. John Wiley & Sons Inc. Hoboken, New Jersey. ISBN 978-3-527-32758-4. PP. 157-187. Galera-Prat, A., Hermans, R. Hervás, R., Gómez-Sicilia, A. & Carrión-Vázquez, M.
    • Imaging biological samples using atomic force microscopy. En: Yuste, R. (Ed.) Imaging: A Laboratory Manual (2010). Ed. Cold Spring Harbor Laboratory Press. New York. ISBN 978-0-87969-935-2 (tapa dura) y 978-0-87969-936-9 (tapa blanda). PP. 585-595. De Pablo, P.J. & Carrión-Vázquez, M.
    • Protein mechanics at the single-molecule level. En: Meyers, R. A. (Ed.). Encyclopedia of Complexity & System Science (2009). Ed. Springer-Verlag. Berlin, Heidelberg. ISBN 978-0-387-75888-6. PP. 7026-7051. Carrión-Vázquez, M., Cieplak, M., and Oberhauser, A.F.
    • Protein nanomechanics, as studied by AFM Single-Molecule Force Spectroscopy. En: Arrondo, J.L.R., and Alonso, A (Eds.)
      Advanced Techniques in Biophysics (2006). Ed. Springer-Verlag. Berlin, Heidelberg. ISBN 978-3-540-30700-6. PP. 163-245. Carrión-Vázquez, M., Oberhauser, A.F., Díez, H., Hervás, R., Oroz, J., Fernández, J., and Martínez-Martín, D.
    • Mechanical design of proteins studied by single-molecule force spectroscopy and protein engineering. En: Leuba, S.H. & Zlatanova, J. (Eds.). Biology at the Single-Molecule Level (2001)
      Ed. Elsevier-Pergamon Press. Oxford. PP. 63-91. Carrión-Vázquez, M., Oberhauser, A.F., Fisher, T.E., Marszalek, P.E., Li, H. and Fernández, J.M.

    Patents and spin-offs

    • Disrupep. Drug for the prevention and treatment of posttraumatic stress disorder (PTSD). Proposed solution
      QBP1 as a CPEB3 activation inhibitor. European patent
      No. 3280430. More information https://disrupep.com/
    • Inventors (P.O. of signature): Carrión-Vázquez, M. and Vera, A.
      Title: Direct measurement system of protein-protein interactions. Application No.: P201530549. Priority country: Spain. Titular Entity: CSIC. Date: April 23, 2015
    • Inventors (P.O. of signature): Carrión-Vázquez, M. and Hervás, R.
      Title: Use of QBP1 Peptide for the Inhibition of Memory Consolidation. Application No.: Spain (EP15382176.4), PCT/EP2016/057801, USA (15/565409), Europe (16725038)
      Country of priority: Spain, USA, Europe. Titular Entity: CSIC. Date: April 10, 2015
    • Inventors (firm p.O): Carrión-Vázquez M, Oroz, J., and Hervás, R. Title: expression vectors in nanomechanics of protein and its application in therapy and diagnosis. Application No.: P201031846, PCT/ES2011/070867. Priority country: Spain. Titular Entity: CSIC-CIBERNED
    • Inventors (firm p.O): Carrión-Vázquez M, Gómez-Herrero J, Valbuena A. Title: Digital interface for the integration of the image mode into a monomolecular force spectroscope. Application No.: P200701859, PCT/ES2008/070130. Priority country: Spain. Titular Entity: CSIC-UAM

    Collaborations

    NACIONAL

    • Douglas Laurents, Instituto Rocasolano de Química-Física/CSIC. Madrid
    • Marta Bruix, Instituto Rocasolano de Química-Física/CSIC. Madrid
    • Margarita Menéndez, Instituto Rocasolano de Química-Física/CSIC. Madrid
    •  Raúl Pérez Jiménez, Nanogune, San Sebastián, Spain
    •  José Luis Trejo, Instituto Cajal, Spain
    •  Ignacio Torres Alemán, Instituto Cajal, Spain
    •  José María Valpuesta, Centro Nacional de Biotecnología/CSIC, Spain
    • Julio Gómez Herrero, Universidad Autónoma de Madrid

    INTERNACIONAL

    • Edward Bayer, Weizmann Institute. Israel
    • Kausik Si, Stowers Institute for Medical Research, Kansas City, MO, EE.UU.
    • Yoshitaka Nagai, Osaka University, Japón
    • Marek Cieplak, Polish Academy of Sciences. Polonia
    • Damien Thompson, University of Limerick, Irlanda
    • Ulrich Müller, Scripps Clinic. La Jolla, CA, EE.UU.
    Science dissemination

    • 2008. Carrión-Vázquez, M. The genetic revolution. In: Sciences for the contemporary world (several authors). Editorial Santillana, Madrid.
    • 2007. Carrión-Vázquez, M. Nanomechanics of Proteins. In: Research and Science 370. PP 45-53

    Funding

    • PID2020-117847RB-I00
      National Plan Program project (MICINN)
      Challenges of society. Development of new inhibitors for functional and pathological amyloids based on the QBP1 peptide
      Principal investigator. Endowment: 187.500 €
    • IND2020/BMD-17444
      Aid for the realization of industrial doctorates
      Madrid’s community. QBP1 anti-amyloidogenic peptide as prevention and therapy for posttraumatic stress disorder. Individual endowment: € 87,013. Total endowment: 147.013 €
    • PIE 202020E026
      Extraordinary Intramural Project (CSIC). CPEB3 and XYN17A, two new biomolecular condensate -forming proteins: molecular bases, biological functions and biomedical and biomanological applications. Endowment: 125.000 €
    • EIN2019-103492
      “Europe research” project (MICINN). Revolutionizing the future of social communication with memical engineering. Endowment: 19.500 €
    • FETOPEN-899616
      New Blue Revolution through a pioneering pathogen-trapping technology based on bioselective hydrogel-forming proteins
      Coordinador Científico (consorcio PathoGelTrap) e investigador principal. Dotación individual: 866.500 €. Dotación consorcio: 3 M €. Enlace: pathogeltrap.eu
    • EUIN2017-85714
      “Europe research” project 2017 (Mineco). Consolidated bioprocessing of lignocellulosic waste in biofuels by optimization of pretreatment, celulesomas of design and improving strains. Endowment: 25.000 €
    • SAF2016-76678-C2-1-R
      Coordinated project of the National Program of the National Plan (Mineco), challenges of society. Molecular determinants of the prionoid domains of functional amyloid versus pathological: towards the development of new inhibitors with therapeutic applications. Main coordinator and researcher.
      Individual endowment: € 187,000. Partner: Dr. Douglas Laurents (Rocasolano Institute)
    • JPND_CD_FP-688-059
      European Coordinated Project of the US Joint Program in neurodegenerative desire. IDENTIFICATION AND STRUCTURAL CHARACTERITION OF THE PRIMORDIAL CYTOTOXIC
      Coordinator (Missinglink consortium) and principal researcher. Individual endowment: € 100,000. Partners: Dr. Douglas Laurents (Rocasolano Institute), Marek Cieplak (Polish Academy of Sciences) and Damien Thompson (Limerick University). Consortium endowment: € 367,900
    • SAF2013-49179-C2-1-R
      Coordinated project of the National Program of the National Plan (Mineco), challenges of society. QBP1 as a prophylactic agent in PTSD: Structural and preclinical studies. Main coordinator and researcher. Individual endowment: € 169,000. Partner: Dr. Douglas Laurents (Rocasolano Institute)
    • NMP-FP7 604530-2
      CellulosomePlus. Grant from the 7FP on NMP (Nanosciences, Nanotechnologies, Materials and new Production Technologies)
      Boosting Lignocellulose Biomass Deconstruction with Designer Cellulosomes for Industrial Applications. Coordinador (consorcio CellulosomePlus) e investigador principal. Dotación individual: 1,178.477 €. Dotación consorcio: 4 M €
    • EIB.12.022 (MINECO: PCIN-2013-011-C02-01)
      Era-Ib Grant from the 7fp. Improved cellulosomes to enhance saccharification of industrially suitable lignocellululosic biomass reside. Coordinator (Fiberfuel Consortium) and principal researcher. Individual endowment: € 100,000. Consortium endowment: € 640,775

    Neuroscience Research Center dependent on the CSIC. Founded in 1920 and initially directed by Santiago Ramón y Cajal. World reference in the study of the brain. Custodian of the Cajal Legacy. 

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