Sensing Developmental Timing


Nuria M Romero

Date and time

May 5 2023 12:30


Instituto Cajal


The timing at which Juvenile-to-adult developmental transition (JDT) occurs defines the right moment to tilt the resources from growth to reproduction. JDT is a maturation process arising after the activation of the neuroendocrine axis. Therefore, complex crosstalk between growth/metabolism and the neuroendocrine axis
has been established in vertebrates and invertebrates. Nevertheless, several observations support that JDT timing determination also require the integration of non-metabolic information. Emblematic examples of this include delayed maturation in isolated rats, advanced development of chickens exposed to high temperatures, and early pupation in infected female mosquitoes. Such unknown non-metabolic integration cries out for an explanation. This seminar will summarize our recent results regarding how the neuroendocrine system integrates non-metabolic environmental signals. For this, we use the Drosophila model, in which we and others have established that the neuroendocrine axis shows several structural and functional parallels even with mammals.

Related publications with the topic 

A 2021. Timing the juvenile-adult neurohormonal transition: functions and evolution. Front. Endocrinol. Feb 12. 2021 Review. Barredo CG, Gil-Marti B, Deveci D, ROMERO NM* and
Martin FA*. *Corresponding Author

2020. Growth and maturation in development: a fly’s perspective. Int J Mol Sci. 2020. Feb 13;21(4):1260. Review. Delanoue R, ROMERO NM*. *Corresponding Author 2019. AstA signaling functions as an evolutionary conserved mechanism timing juvenile to adult transition. Curr Biol. 2019. Mar 4;29(5):813-822.e4. Deveci D, Martin FA, Leopold P, ROMERO NM*. *Corresponding Author

2018. Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing. Development 2018. Mar 4;145(6):dev159699. Shimell M, Pan X, Martin FA, Ghosh AC, Leopold P, O’Connor MB, ROMERO NM*. *Corresponding Author

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