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Publicaciones 2017

  • Michael Seagar, Michael Russier, Olivier Caillard, Yves Maulet, Laure Fronzaroli-Molinieres, Marina De San Feliciano, Norah Boumedine-Guignon, Léa Rodriguez, Mickael Zbili, Fabrice Usseglio, Christine Formisano-Tréziny, Fahamoe Youssouf, Marion Sangiardi, Morgane Boillot, Stéphanie Baulac, María José Benitez, Juan José Garrido, Dominique Debanne, and Oussama El Far (2017).LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels.Proceedings of the National Academy of Sciences (PNAS), 114 (29): 7719-7724 (2017). doi:10.1073/pnas.1618656114.

Publicaciones 2015

  • M. Valero, E. Cid, RG. Averkin, J.Aguilar, A. Sanchez-Aguilera, TJ. Viney, D.Gomez-Dominguez, E. Bellistri, L. Menendez de la Prida. Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples. Nature Neuroscience 18, 1281–1290 (2015).

  • C. Alvarado-Rojas, G. Huberfeld, M. Baulac, S. Clemenceau, S. Charpier,R. Miles, L. Menendez de la Prida*CA, M. Le Van Quyen. Different mechanisms of ripple-like oscillations in the human epileptic subiculum. Ann Neurol. 77(2):281-90 (2015).

  • F.Laurent, JR. Brotons-Mas, E.Cid, D.Lopez-Pigozzi, M.Valero, B.Gal, L.Menendez de la Prida. Proximodistal structure of theta coordination in the dorsal hippocampus of epileptic rats. J Neuroscience. 35(11): 4760-4775 (2015)

Publicaciones 2014

  • López-Sánchez N, Frade JM (2014) Flow cytometric analysis of DNA synthesis and apoptosis in the central nervous system using fresh cell nuclei. Methods Mol. Biol. (en prensa).

  • Galan A, Dergham P, Escoll P, de la Hera A, D’Onofrio PM, Magharious MM, Koeberle PD, Frade JM, Saragovi HU (2014) Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cells. PLoS One 9: e101349.

  • Ana del Puerto, Laure Fronzaroli-Molinieres, María José Perez-Alvarez, Pierre Giraud, Edmond Carlier, Francisco Wandosell, Dominique Debanne and Juan José Garrido. ATP-P2X7 Receptor modulates Axon Initial Segment Composition and Function in Physiological Conditions and Brain Injury. Cerebral Cortex (2014) doi:10.1093/cercor/bhu035

  • Benitez MJ, Sanchez-Ponce D, Garrido JJ*, Wandosell F*. Hsp90 activity is necessary to acquire a proper neuronal polarization. Biochim Biophys Acta. 1843(2):245-52 (2014). *Corresponding authors.

  • P.Aivar, M.Valero, E.Bellistri, L.Menendez de la Prida (2014) Extracellular calcium controls the expression of two different forms of ripple-like hippocampal oscillations. J Neuroscience. 34(8): 2989-3004).

Publicaciones 2013

  • A.Altuna, E.Bellistri, E.Cid, P.Aivar, B.Gal, J.Berganzo, G.Gabriel, A.Guimerà, R.Villa, LJ.Fernández, L.Menendez de la Prida. (2013) SU-8 based microprobes for simultaneous neural depth recording and drug delivery in the brain. Lab Chip. 2013 Feb 14.

  • E.Bellistri, J.Aguilar, JR.Brotons-Mas, G.Foffani, L.Menendez de la Prida. (2013) Basic properties of somatosensory-evoked responses in the dorsal hippocampus of the rat. J Physiol. Mar 25.

  • M.Inostroza, JR.Brotons-Mas, F.Laurent, E.Cid, L.Menendez de la Prida. (2013) Specific impairment of “What-Where-When” episodic-like memory in experimental models of temporal lobe epilepsy. J Neuroscience. 33(45): 17749-17762.

  • Martín-Vázquez G, Makarova J, Makarov VA, and Herreras O (2013) Determining the true polarity and amplitude of synaptic currents underlying gamma oscillations of local field potentials. PLoS ONE 8(9): e75499.

  • del Puerto A, Wandosell F and Garrido JJ (2013) Neuronal and glial purinergic receptors functions in neuron development and brain disease. Front. Cell. Neurosci. 7:197: 1-15

  • Fernández-Ruiz A, Muñoz S, Sancho M, Makarova J, Makarov VA, and Herreras O. (2013) Cytoarchitectonic and dynamic origins of giant positive LFPs in the Dentate Gyrus. Journal of Neuroscience 33:15518-32

  • Tapia M, Del Puerto A, Puime A, Sánchez-Ponce D, Fronzaroli-Molinieres L, Pallas-Bazarra N, Carlier E, Giraud P, Debanne D, Wandosell F, Garrido JJ. GSK3 and β-catenin determines functional expression of sodium channels at the axon initial segment. Cell Mol Life Sci. 2013 Jan;70(1):105-20.

  • Simon D, Herva ME, Benitez MJ, Garrido JJ, Rojo AI, Cuadrado A, Torres JM, Wandosell F. Dysfunction of the PI3K-Akt-GSK-3 pathway is a common feature in cell culture and in vivo models of prion disease. Neuropathol Appl Neurobiol. 2013 Jun 6. doi: 10.1111/nan.12066.

  • Fernández-Ruiz A and Herreras O (2013) Identifying the synaptic origin of ongoing neuronal oscillations through spatial discrimination of electric fields. Front. Comput. Neurosci. 7:5. doi: 10.3389/fncom.2013.00005

  • Varea O, Escoll M, Diez H, Garrido JJ, Wandosell F. Oestradiol signalling through the Akt-mTORC1-S6K1. Biochim Biophys Acta. 2013 May;1833(5):1052-64.

  • López-Jiménez A, Walter NA, Giné E, Santos A, Echeverry-Alzate V, Bühler KM, Olmos P, Giezendanner S, Moratalla R, Montoliu L, Buck KJ, López-Moreno JA. (2013) A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: Effects on alcohol consumption. Synapse,67:280-9. IF=2.95

  • Ares-Santos S, Granado N, Moratalla R. (2013) The role of dopamine receptors in the neurotoxicity of methamphetamine. J Intern Med. 2013; 273:437-53. IF=5.48

  • Benito N, Fernández-Ruiz A, Makarov VA, Makarova J, Korovaichuk A, and Herreras O. (2013) Spatial modules of coherent activity in pathway-specific LFPs in the hippocampus reflect topology and different modes of presynaptic synchronization. Cerebral Cortex, DOI: 10.1093/cercor/bht022.

  • Granado N, Ares-Santos S, Moratalla R. (2013) Methamphetamine and Parkinson's disease. Parkinsons Dis.;2013:308052. doi: 10.1155/2013/308052. Epub 2013 Feb 7. IF=1.08

  • Peraile I, Granado N, Torres E, Gutiérrez-López MD, Moratalla R, Colado MI, O'Shea E. (2013) Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders. Psychopharmacology (Berl). IF=4,08

  • Hai-Ying S, Canas PM, Garcia-Sanz P, Boison D, Moratalla R, Cunha RA, Chen JF. (2013) Adenosine A2A receptor in striatal glutamatergic terminal and GABAergic neuron oppositely modulate psychostimulant action and DARPP-32 phosphorylation. PLoS One, en prensa IF=4.09

  • Dreier JP, Isele T, Reiffurth C, Offenhauser N, Kirov SA, Dahlem MA, and Herreras O. (2013) Is Spreading Depolarization Characterized by an Abrupt, Massive Release of Gibbs Free Energy from the Human Brain Cortex? Neuroscientist. Feb; 19(1):25-42. doi: 10.1177/1073858412453340.

  • Suárez LM, Solís O, Caramés JM, Taravini IR, Solís JM, Murer MG, Moratalla R. (2013) L-DOPA treatment selectively restores spine density in D2R-expressing projection neurons in dyskinetic mice. Biological Psychiatry, aceptado (PBS-114848) IF=9.24

  • Gonzalez-Aparicio R, Moratalla R. (2013) Oleoylethanolamide reduces L-Dopa-induced dyskinesias via TRPV1 receptor in a mouse model of Parkinson´s Disease. Neuorol Dis,. IF=5.63

  • Gire, D.H., Restrepo, D., Sejnowski,T.J. Greer, C., De Carlos,J.A. and Lopez-Mascaraque, L. 2013 Temporal Processing in the Olfactory System: CanWe See a Smell?. Neuron, 78:416-432.

  • García-Marqués and López-Mascaraque, L. 2013. Clonal Identity Determines Astrocyte Cortical Heterogeneity. Cerebral Cortex, 23:1463–1472.

  • A.Altuna, E.Bellistri, E.Cid, P.Aivar, B.Gal, J.Berganzo, G.Gabriel, A.Guimerà, R.Villa, LJ.Fernández, L.Menendez de la Prida. SU-8 based microprobes for simultaneous neural depth recording and drug delivery in the brain. Lab Chip. 2013 Feb 14 (2013).

  • Ovejero-Benito MC y Frade JM (2013) Brain-derived neurotrophic factor-dependent cdk1 inhibition
    prevents G2/M progression in differentiating tetraploid neurons
    . PLoS One 5: e64890. doi:10.1371/journal.pone.0064890.

  • Formosa-Jordan P, Ibañes M, Ares S, y Frade JM (2013) Lateral inhibition and neurogenesis: novel aspects in motion. Int. J. Dev. Biol. 57: 341-350.

  • López-Sánchez N y Frade JM (2013) Genetic evidence for p75NTR-dependent tetraploidy in cortical projection neurons from adult mice. J. Neurosci., 33: 7488-7500.

Publicaciones 2012

  • Ares-Santos S, Granado N, Oliva I, O'Shea E, Martin ED, Colado MI, Moratalla R. (2012) Dopamine D(1) receptor deletion strongly reduces neurotoxic effects of methamphetamine. Neurobiol Dis. 45:810-820 IF=5.63

  • Madronal N, Gruart A, Valverde O, Espadas I, Moratalla R, Delgado-Garcia JM. (2012) Involvement of cannabinoid CB1 receptor in associative learning and in hippocampal CA3-CA1 synaptic plasticity. Cerebral Cortex; 22:550-556 IF=6.84

  • Fernández-Ruiz A, Makarov VA, and Herreras O. (2012) Sustained increase of spontaneous input and spike transfer in the CA3-CA1 pathway following long term potentiation in vivo. Front. Neural Circuits, 6:71.

  • Espadas I, Darmopil S, Vergaño-Vera E, Ortiz O, Oliva I, Vicario-Abejón C, Martín ED, Moratalla R. (2012) L-DOPA-induced increase in TH-immunoreactive striatal neurons in parkinsonian mice: Insights into regulation and function. Neurobiol Dis.; 48:271-81 IF=5.63

  • Busceti CL, Bucci D, Molinaro G, Di Pietro P, Zangrandi L, Gradini R, Moratalla R, Battaglia G, Bruno V, Nicoletti F, Fornai F. (2012) Lack or inhibition of dopaminergic stimulation induces a development increase of striatal tyrosine hydroxylase-positive interneurons. PLoS One;7:e44025. doi: 10.1371/journal.pone.0044025. Epub 2012 Sep 18. IF=4.09

  • Fernández-Ruiz A, Makarov VA, Benito N, and Herreras O. (2012) Schaffer-specific local field potentials reflect discrete excitatory events at gamma-frequency that may fire postsynaptic hippocampal CA1 units. Journal of Neuroscience. 32:5165-5176

  • Sara Arganda, Alfonso Pérez-Escudero & Gonzalo G. de Polavieja 'A common rule for decision making in animal collectives across species '10.1073/pnas.1210664109 PNAS November 28, 2012.

  • Díez H, Garrido JJ, Wandosell F. Specific roles of Akt iso forms in apoptosis and axon growth regulation in neurons. PLoS One. 2012;7(4):e32715. Epub 2012 Apr 11.

  • Mónica Tapia, Ana del Puerto, Alberto Puime, Diana Sánchez-Ponce, Laure Fronzaroli-Molinieres, Noemí Pallas-Bazarra, Edmond Carlier, Pierre Giraud, Dominique Debanne, Francisco Wandosell, and Juan José Garrido. GSK3 and beta-catenin determines functional expression of sodium channels at the axon initial segment. Cellular and Molecular Life Sciences. (2012). DOI 10.1007/s00018-012-1059-5.

  • Gómez-Galán M, Makarova J, Llorente-Folch I, Saheki T, Pardo B, Satrústegui J, and Herreras O. (2012) Altered postnatal development of cortico-hipocampal neuronal electric activity in mice deficient for the mitochondrial aspartate-glutamate transporter. J. Cereb. Blood Flow Metab 32, 306–317

  • Gascuel, J., Lemoine, A., Rigault, C., Datiche, F., Benani, A., Penicaud, L. and López-Mascaraque, L. 2012. Hypothalamus-olfactory system crosstalk: orexin A immunostaining in mice. Frontiers in Neuroanatomy, 6:44. doi: 10.3389/fnana.2012.00044.

  • Jordan-Álvarez, S.; Fouquet W.; Sigrist, S.J. and Acebes, A.*Presynaptic PI3K activity triggers the formation of glutamate receptors at neuromuscular terminals of Drosophila. J. Cell Sci.
    (*Corresponding Author).

  • Martín-López, Corona, R. and López-Mascaraque, L. 2012. Postnatal characterization of cells in the accessory olfactory bulb of wild type and reeler mice. Frontiers in Neuroanatomy, 6:15. doi: 10.3389/fnana.2012.00015.

  • Morillo SM, Abanto E, Román MJ y Frade JM (2012) NGF-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation. Mol. Cell. Biol. 32: 2722-2737.

  • Formosa P, Ibañes M, Ares S y Frade JM (2012) Regulation of neuronal differentiation at the neurogenic wave front. Development 139: 2321-2329.

  • Santos AM, López-Sánchez N, Martín-Oliva D, de la Villa P, Cuadros MA y Frade JM (2012) Sortilin participates in light-dependent photoreceptor degeneration in vivo. PLoS One 7: e36243.

Publicaciones 2011

  • Suárez J, Ortiz O, Puente N, Bermúdez-Silva FJ, Blanco E, Fernández-Llebrez P, Grandes P, de Fonseca FR, Moratalla R. (2011) Distribution of diacylglycerol lipase alpha, an endocannabinoid synthesizing enzyme, in the rat forebrain. Neuroscience, 192:112-31. IF=3,22

  • Murer MG, Moratalla R. (2011) Striatal Signaling in L-DOPA-Induced Dyskinesia: Common Mechanisms with Drug Abuse and Long Term Memory Involving D1 Dopamine Receptor Stimulation. Front Neuroanat.; 5:51.

  • Antonelli MC, Guillemin GJ, Raisman-Vozari R, Del-Bel EA, Aschner M, Collins MA, Tizabi Y, Moratalla R, West AK. (2011) New Strategies in Neuroprotection and Neurorepair. Neurotox Res.; 21:49-56 IF=3,02

  • Granado N, Ares-Santos S, Oliva I, O'Shea E, Martin ED, Colado MI, Moratalla R. (2011)Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA. Neurobiol Dis., 42:391-403. IF=5,63

  • Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluís C, Moratalla R, Ferré S, Ortiz J, Franco R. (2011) Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway. J Biol Chem.; 286:5846-54. IF=5,33

  • Johnson PL, Fitz S, Hollis J, Moratalla R, Lightman SL, Shekhar A, Lowry CA. (2011) Induction of c-Fos in “panic/defense”-related brain circuits following brief hypercarbic gas exposure. J Psychopharmacol,; 25:26-36. IF= 4,06

  • Granado N, Lastres-Becker I, Ares-Santos S, Oliva I, Martin E, Cuadrado A, Moratalla R. (2011) HYPERLINK Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum. Glia, 59:1850-63 IF=5.19

  • Makarova J, Ibarz JM, Makarov VA, Benito N, and Herreras O. (2011). Parallel Readout of Pathway-Specific Inputs to Laminated Brain Structures. Front. Syst. Neurosci. 5:77.

  • Méndez-Gómez HR, Vergaño-Vera E, Abad JL, Bulfone A, Moratalla R, de Pablo F, Vicario-Abejón C. (2011) The T-box brain 1 (Tbr1) transcription factor inhibits astrocyte formation in the olfactory bulb and regulates neural stem cell fate. Mol Cell Neurosci.; 46:108-21 IF=3.86

  • G.Huberfeld, L.Menendez de la Prida, J.Pallud, I.Cohen, M.l Le Van Quyen,C.Adam,Clemenceau,.M.Baulac, R.Miles Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy. Nat Neu 14:627-634 (2011)

  • M.Inostroza, E.Cid, J.Brotons-Mas, B.Gal, P.Aivar, Y.G.Uzcategui, C.Sandi, L.Menendez de la Prida
    Hippocampal dependent spatial memory in the water maze is preserved in an experimental models of temporal lobe epilepsy. PLoS ONE 6(7) e22372 (2011)

  • Ballesta, J., Cremades, J., Rodríguez-Muñoz, M., Garzón, J., Faura, C.: “Sensitivity to µ opioid receptor-mediated antinociception is determined by cross-regulation between µ and δ opioid receptors at supraspinal level” Br J Pharmacol doi: 10.1111/j.1476-5381.2011.01750.x (2011). PMID: 22023056.

  • Alba-Delgado, C., Borges, G., Sánchez-Blázquez, P., Ortega, J.E., Horrillo, I., Micó, J.A., Meana, J., Neto, F., Berrocoso, E.: “The function of alpha-2-2adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain” Psychopharmacology doi: 10.1007/s00213-011-2542-7 (2011). PMID: 22038538.

  • Garzón, J., Rodríguez-Muñoz, M., Vicente-Sánchez, A., García-López, MA., Martínez-Murillo, R., Fischer, T., Sánchez-Blázquez, P.: “SUMO-SIM interactions regulate the activity of RGSZ2 proteins” PlosOne 6(12): e28557 (2011). PMID: 22163035.

  • M. Rivera-Alba, S. N. Vitaladevuni, Y. Mischenko, Z. Lu, S. Takemura, L. Scheffer, I. A. Meinertzhagen, D. B. Chklovskii & G.G. de Polavieja, 'Wiring economy and volume exclusion determine neuronal placement in the Drosophila brain', Current Biology 21, 2000 (2011).

  • Blanchart, A. and López-Mascaraque, L. 2011. From the periphery to the brain: wiring the olfactory system. Translational Neuroscience, 2(4): 293-309.

  • A. Pérez‐Escudero y G. G. de Polavieja, Collective Animal Behavior from Bayesian Estimation and
    Probability Matching.
    PLoS Computational Biology. DOI: 10.1371/journal.pcbi.1002282.

  • Herreras O. (2011) The Whole and The Parts, Development and Aging, Life and Death. J. Cereb. Blood Flow Metab., 31:994-995.

  • Acebes, A.; Devaud, J.-M.; Arnés, M. and Ferrús, A. Central adaptation to odorants depends on PI3K levels in local interneurons of the antennal lobe. Journal of Neuroscience (in press).

  • Acebes, A. and Morales, M. At a PI3K crossroads: lessons from flies and rodents. Reviews in the Neurosciences (in press).

  • Ruiz, M.; Sánchez, D.; Canal, I.; Acebes, A. and Ganfornina, M.D. (2011) Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz. Experimental Gerontology 46: 579-589.

  • Acebes, A.; Martín-Peña, A.; Chevalier, V. and Ferrús, A (2011) Synapse loss in olfactory local interneurons modifies perception. Journal of Neuroscience 31: 2734-2745.

  • Cuesto, G.; Enriquez-Barreto L.; Carames, C.; Cantarero, M.; Gasull, X.; Sandi,C.; Ferrus, A.; Acebes, A. and Morales, M. (2011) PI3K activation controls synaptogenesis and spinogenesis in hippocampal neurons. Journal of Neuroscience 31: 2721-2733.

  • Gradilla AC.; Mansilla, A. and Ferrús, A. (2011) Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin-ligase in Drosophila melanogaster. Genetics 189, 1-13.

  • Martin-López, E., Blanchart, A., De Carlos, J. A. and Laura López-Mascaraque, L. 2011. DAB1 (Disable homolog-1) reelin adaptor protein is overexpressed in the olfactory bulb at early postnatal stages. PLoS ONE. (in press).

  • Ana del Puerto, Juan-Ignacio Díaz-Hernández, Mónica Tapia, Rosa Gomez-Villafuertes, María José Benitez, Jin Zhang, María Teresa Miras-Portugal, Francisco Wandosell, Miguel Díaz-Hernández and Juan José Garrido. Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13, and ATP-gated P2X7 receptors on axonal elongation. Journal of Cell Science (accepted manuscript, in press)

  • Juan Ignacio Diaz-Hernandez, Rosa Gomez-Villafuertes, Miriam León-Otegui, Lourdes Hontecillas-Prieto, Ana del Puerto, Jose Luis Trejo, Jose Javier Lucas, Juan Jose Garrido, Javier Gualix, Maria Teresa Miras-Portugal. In vivo P2X7R inhibition reduces amyloid plaques in Alzheimer Disease through GSK3-beta and secretases. Neurobiology of Aging (accepted manuscript, in press)

  • Sánchez-Ponce D, Blázquez-Llorca L, Defelipe J, Garrido JJ, Muñoz A. Colocalization of {alpha}-actinin and Synaptopodin in the Pyramidal Cell Axon Initial Segment. Cerebral Cortex. Sep 21. [Epub ahead of print]

  • Miguel Medina, Juan José Garrido, Francsico Wandosell Modulation of GSK-3 as a therapeutic strategy on tau pathologies Frontiers in Molecular Neuroscience, September 2011, Volume 4 Article 24

  • Franco A, Knafo S, Banon-Rodriguez I, Merino-Serrais P, Fernaud-Espinosa I, Nieto M, Garrido JJ, Esteban JA, Wandosell F, Anton IM. WIP Is a Negative Regulator of Neuronal Maturation and Synaptic Activity. Cerebral Cortex. 2011 Aug 1. [Epub ahead of print]

  • Sánchez-Ponce D, DeFelipe J, Garrido JJ, Muñoz A. In vitro maturation of the cisternal organelle in the hippocampal neuron's axon initial segment. Mol Cell Neurosci. 2011 Sep;48(1):104-16.

  • Sanchez-Ponce D, Muñoz A, Garrido JJ. Casein kinase 2 and microtubules control axon initial segment formation. Mol Cell Neurosci. 2011 Jan; 46(1):222-34.

  • Rodríguez-Muñoz, M., Sánchez-Blazquez, P., Vicente-Sánchez, A., Bailón, C., Martín Aznar, B., Garzón, J.: “The histidine triad nucleotide binding protein 1 supports Mu-opioid receptor-glutamate NMDA receptor cross-regulation” Cell & Mol Life Sci 68, 2933-2949 (2011). PMID: 21153910.

  • Rodríguez-Muñoz, M., Sánchez-Blazquez, P., Vicente-Sánchez, A., Berrocoso, E., y Garzón, J.: “The Mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control” Neuropsychopharmacology doi:10.1038/npp.2011.155 (2011). PMID: 21814188.

  • Blanchart, A., Martín-López, E., De Carlos, J.A. and López-Mascaraque, L. (2011). Peripheral contributions to Olfactory Bulb cell populations (Migrations towards the Olfactory Bulb). Glia, 59: 278-292.

  • Garzón, J., Rodríguez-Muñoz, M., Vicente-Sánchez, A., Bailón, C., Martínez-Murillo, R.,Sánchez Blázquez, P.: “RGSZ2 binds to the nNOS PDZ domain to regulate Mu-opioid receptor-mediated potentiation of the NMDAR-CaMKII pathway” Antioxid Redox Signal 15, 873-887 (2011). PMID: 21348811

  • Harrison NC, Diez del Corral R, Vasiev B (2011) Coordination of Cell Differentiation and Migration in Mathematical Models of Caudal Embryonic Axis Extension. PLoS ONE 6(7): e22700. doi:10.1371/journal.pone.0022700. Abstract

  • Martínez-Morales,P. L., Diez del Corra, R., Olivera-Martínez, I., Quiroga, A. C., M. Das, R., Barba, J.A., Storey K.G. and V. Morales, A.V. (2011) FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk. The Journal of Cell Biology. 194:489-503. Doi:10.1083/jcb.201011077.Abstract.

  • Rodríguez Muñoz, M., De la Torre-Madrid, E., Sánchez Blázquez, P., Garzón, J.: “NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the Mu-opioid receptor” Antioxid Redox Signal 14, 2413-2425 (2011). PMID: 21235400

  • Sorribes, A. , Armendariz, B.G , Lopez-Pigozz, D.i, Murga, C.& de Polavieja, G. Origin of behavioral bursts in decision-making circuitry, PLoS Comput Biol 7(6): e1002075. doi:10.1371/journal.pcbi.1002075 (2011)

Publicaciones 2010

  • Granado N, Ares-Santos S, O'Shea E, Vicario-Abejón C, Colado MI, Moratalla R. (2010). Pubmed_DefaultReportPanel.Pubmed_RVDocSum" Selective Vulnerability in Striosomes and in the Nigrostriatal Dopaminergic Pathway After Methamphetamine Administration: Early Loss of TH in Striosomes After Methamphetamine. Neurotox Res., 18: 48-58. IF=3,02

  • Ramiro-Fuentes S, Ortiz O, Moratalla R, and E Fernandez-Espejo. (2010) Intra-accumbal rimonabant is rewarding but induces aversion to cocaine in cocaine-treated rats, as does in vivo CB1R silencing: critical role for glutamate receptors. Neuroscience, 167:205-215. IF=3,22

  • Gramage E, Rossi L, Granado N, Moratalla R, Herradón G. (2010) Genetic inactivation of pleiotrophin triggers amphetamine-induced cell loss in the substantia nigra and enhances amphetamine neurotoxicity in the striatum. Neuroscience, 170: 308-316. IF=3,22

  • Ortiz O, Delgado-García JM, Espadas I, Dreyer JL, Bahí A, Trullas R, Gruart A and R Moratalla. (2010) Associative learning and CA3-CA1 synaptic plasticity are impaired in D1R null mice and hippocampal siRNA silenced D1R mice. J Neurosci, 30:12288-12300, IF= 7,8

  • Sánchez-Blázquez P., Rodríguez-Muñoz, M. Garzón, J.: “Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling” PlosOne 5(6), e11278 (2010). PMID: 20585660

  • Korovaichuk A, Makarova J, Makarov VA, Benito N, and Herreras O. (2010). Minor contribution of principal excitatory pathways to hippocampal LFPs in the anesthetized rat: a combined independent component and current source density study. Journal of Neurophysiology 104:484-497.

  • Miquelajáuregui, A., Valera-Echavarría, A., Ceci, M.L., García-Moreno, F., Hoang, K., Ricaño, I., Chowdhury, T.G., Portera-Cailliau, C., Tamariz, E., De Carlos, J.A., Westphal, H. and Zhao, Y. 2010. LIM-homeobox gene Lhx5 is required for normal development of Cajal-Retzius cells. J. Neurosci., 30 (31): 10551-10562.

  • Blanchart, A, Martín-López, E., De Carlos, J.A. and López-Mascaraque. 2010. Peripheral contributions to Olfactory Bulb cell populations. Glia (en prensa).

  • Nikoletopoulou V, Lickert H, Frade JM, Rencurel C, Zhang L, Bibel M, Barde YA (2010) Neurotrophin receptors TrkA and TrkC but not TrkB cause neuronal death. Nature 467: 59-64.

  • Fuenzalida M, Fernández de Sevilla D, Couve A, Buño W. Role of AMPA- NMDA-receptors and back-propagating action potentials in spike-timing dependent plasticity. J. Neurophysiol. 103:47-54, 2010.

  • Cabezas C, Buño W. BDNF is required for the induction of a presynaptic component of the functional conversion of silent synapses. Hippocampus, 2010, Jan 15. [Epub ahead of print] Published Online: Jan 15, 2010, 12:19PM, DOI: 10.1002/hipo.20754.

  • Fernández de Sevilla D, Buño W.The Muscarinic Long-Term Enhancement of NMDA and AMPA Receptor-Mediated Transmission at Schaffer Collateral Synapses Develop through Different Intracellular Mechanisms. J. Neurosci. 30:, 2010 (en Prensa).

  • Frade JM y López-Sánchez (2010) A novel hypothesis for Alzheimer's disease based on neuronal tetraploidy induced by p75NTR. Cell Cycle 9: 1934-1941.

  • García-Moreno, F., Pedraza, M., Di Giovannantonio, L.G., Di Salvio, M., López-Mascaraque, L., Simeone, A. and De Carlos, J.A. (2010) A neuronal migratory pathway crossing brain boundaries populates amygdala nuclei. Nature Neurosci., 13: 680-189.

  • Ceci, M.L., López-Mascaraque, L. and De Carlos, J. A. 2010. The influence of the environment on Cajal-Retzius cell migration. Cereb. Cortex, 20: 2348-2360.

  • Cerciat, M., Unkila, M., García-Segura, L.M., Arevalo, M.A. Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-gamma-inducible protein-10 by astrocytes exposed to inflammatory challenge in vitro. Glia, 58 93-102.

  • Correa, F., Hernangómez, M., Mestr,e L., Lorí,a F., Spagnolo, A., Docagn,e .F, Di Marz,o .V, Guaza, C. Anandamide enhances IL-10 production in activated microglia by targeting CB(2) receptors: Roles of ERK1/2, JNK, and NF-kappaB. Glia, 58 135-47.

  • Frade JM (2010) Somatic tetraploidy in vertebrate neurons: implications in physiology and pathology//. Commun. Integr. Biol. 3: 201-203.

  • García-Álvarez, I., Garrido L., Doncel-Pérez E., Nieto-Sampedr,o M., Fernández-Mayorala,s A. Detection of Metabolite Changes in C6 Glioma Cells Cultured with Antimitotic Oleyl Glycoside by (1)H MAS NMR. J Med Chem (en prensa).

  • Makarova J, Makarov VA, and Herreras O. (2010) Generation of sustained field potentials by gradients of polarization within single neurons: a macroscopic model of spreading depression Journal of Neurophysiology, 103:2446-2457.

  • García-Marqués, J, De Carlos JA, Greer CA, López-Mascaraque L. Different astroglia permissivity controls the migration of olfactory bulb interneuron precursors. Glia, 58 218-30.

  • Granado N, Ares-Santos S, O'Shea E, Vicario-Abejón C, Colado MI, Moratalla R. Selective Vulnerability in Striosomes and in the Nigrostriatal Dopaminergic Pathway After Methamphetamine Administration : Early Loss of TH in Striosomes After Methamphetamine. Neurotox Res. PMID: 19760475 .

  • Gómez-Nicola D, Spagnolo A, Guaza C, Nieto-Sampedro M. Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice. Exp Neurol. 2010 Jan 11. [Epub ahead of print]PMID: 20070942.

  • Gómez-Nicola D, Valle-Argos B, Nieto-Sampedro M. Blockade of IL-15 activity inhibits microglial activation through the NFkappaB, p38, and ERK1/2 pathways, reducing cytokine and chemokine release. Glia. 2010 Feb;58(3): 264-76.

  • Makarov VA, Makarova J, and Herreras O. (2010). Disentanglement of local field potential sources by independent component analysis. J. Computational Neuroscience, 29:445-457.

  • Loría, F., Petrosino, S., Hernangómez, M., Mestre L, Spagnolo, A., Correa F., Di Marzo V., Docagne F., Guaza C. An endocannabinoid tone limits excitotoxicity in vitro and in a model of multiple sclerosis. Neurobiol Dis, 37 166-76.

  • Martínez-Morales, P.L., Quiroga, A.C., Barbas, J. and Morales, A.V. Sox5 controls cell cycle progression in neural progenitors by interfering with Wnt/β-catenin pathway (2010). EMBO reports (doi:10.1038/embor.2010.61; en prensa).

  • Morillo, S.M., Escol, P., de la Hera A., y Frade, J.M. Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. Proc. Natl. Acad. Sci. USA 107: 109-114.

  • Valle-Argos B, Gómez-Nicola D, Nieto-Sampedro M. Synthesis and characterization of neurostatin-related compounds with high inhibitory activity of glioma growth. Eur J Med Chem. 2010 Jan 28. [Epub ahead of print]PMID: 20153569

  • Vergaño-Vera, E., Fernánde,z .A.P, Vicario-Abejón, C., Martínez A. Lack of adrenomedullin affects growth and differentiation of adult neural stem cells. Cell and Tissue Research (En prensa).

  • Yague JG, Azcoitia I, Defelipe J, García-Segura LM, Muñoz A. Aromatase expression in the normal and epileptic human hippocampus. Brain Res (en prensa).

Publicaciones 2009

  • Arevalo MA, Roldan PM, Chacon PJ, Rodríguez-Tebar A 2009 Amyloid beta serves as an NGF-like neurotrophic factor or acts as a NGF antagonist depending in its concentration. Journal of Neurochemistry, 111 1425-1433.

  • Arevalo MA, Santos-Galindo M, Bellini MJ, Azcoitia I, García-Segura LM. 2009 Actions of estrogens on glial cells: Implications for neuroprotection. Biochim Biophys Acta, 150 5010.

  • Barreto G, Santos-Galindo M, Diz-Chaves Y, Pernía O, Carrero P, Azcoitia I, García-Segura LM. 2009 Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. Endocrinology, 150 5010-5.

  • Berrocoso E, Sanchez-Blazquez P, Garzón J, Mico JA. 2009 Opiates as antidepressants. Curr. Pharmac.Desing 15(14):1612-22.

  • Biamonte F, Assenza G, Maríno R, D'Amelio M, Panteri R, Caruso D, Scurati S, Yague JG, García-Segura LM, Cesa R, Strata P, Melcangi RC, Keller F. 2009 Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival. Neurobiol Dis, 36 103-15.

  • Bovolenta, P. and Cisneros, E. 2009 Retinitis pigmentosa: cone photoreceptors starving to death. Nat Neurosci 12, 5-6.

  • Correa F. , Docagne F., Mestre L., Clemente D. , Hernangomez M. , Loria F., Guaza C. A. 2009 Role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells. Biochemical pharmacology, 77 86-100.

  • Darmopil S, Martín AB, De Diego IR, Ares S, Moratalla R. 2009 Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation. Biol Psychiatry, 66 603-13.

  • Doncarlos LL, Azcoitia I, García-Segura LM. 2009 Neuroprotective actions of selective estrogen receptor modulators. Psychoneuroendocrinology, 34S1 S113-S122.

  • Doncel-Pérez E, Caballero-Chacón S, Nieto-Sampedro M. 2009 Neurosphere cell differentiation to aldynoglia promoted by olfactory ensheathing cell conditioned medium. Glia, 57 1393-409.

  • García-Marín V, Blazquez-Llorca L, Rodríguez JR, Boluda S, Muntane G, Ferrer I, Defelipe J. 2009 Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques. Front. Neuroanat;3: 28.

  • García-Ovejero D, Arevalo-Martín A, Petrosino S , Docagne F , Hagen , Bisogno , Watanabe M , Guaza C , Di Matzo V , Molina-Holgado E 2009 The endocannabinoid system is modulated in response to spinal cord injury in rats. Neurobiology of disease, 33 57-71.

  • Garzon J , de la Torre-Madrid E , Rodríguez-Munoz M, Vicente-Sánchez A., Sánchez-Blazquez P. 2009 Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine. Molecular pain, MAR 10,  11.

  • García-Marín V, García-López P, Freire M 2009 The Growth Cone as Seen Through Cajal's Original Histological Preparations and Publications. Journal of the history of the neurosciences, 18 197-210.

  • García-Segura LM, Balthazart J. 2009 Steroids and neuroprotection: New advances. Frontiers in neuroendocrinology , 30 Sp. Iss. SI v-ix.

  • Giatti S, Pesaresi M, Cavaletti G, Bianchi R, Carozzi V, Lombardi R, Maschi O, Lauria G, García-Segura LM, Caruso D, Melcangi RC. 2009 Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy. Neuroscience, 164 520-9.

  • Gómez-Villafuertes, R., del Puerto, A., Díaz-Hernández, M., Bustillo, D., Díaz-Hernández, J., Huerta, P., Artalejo, A., Garrido, J.J., Miras-Portugal, M.T. 2009 Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells. FEBS Journal. 276(18):5307-25.

  • Guerra-Araiza C, Amorim MA, Pinto-Almazán R, González-Arenas A, Campos MG, García-Segura LM. 2009 Regulation of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling pathways by progesterone and its reduced metabolites in the rat brain. J Neurosci Res, 87 470-81.

  • Hernández-Rabaza V, Llorens-Martín M, Velázquez-Sánchez C, Ferragud A, Arcusa A, Gumus HG, Gómez-Pinedo U, Pérez-Villalba A, Roselló J, Trejo JL, Barcia JA, Canales JJ. 2009 Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and spatial reversal. Neuroscience, 159 59-68.

  • Hurtado-Chong A, Yusta-Boyo MJ, Vergaño-Vera E, Bulfone A, de Pablo F, Vicario-Abejón C. 2009. IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone. European Journal of Neuroscience 30, 742-755. PMID: 19712103.

  • Inda MC, DeFelipe J, Munoz A. 2009 Morphology and Distribution of Chandelier Cell Axon Terminals in the Mouse Cerebral Cortex and Claustroamygdaloid Complex. Cereb Cortex. 19(1):41-54.

  • Kastanauskaite A, Alonso-Nanclares L, Blazquez-Llorca L, Pastor J, Sola RG, DeFelipe J. 2009 Alterations of the microvascular network in sclerotic hippocampi from patients with epilepsy. J Neuropathol Exp Neurol. 68:939-50.

  • Knafo S , Venero C, Merino-Serrais P, Fernaud-Espinosa I, Gonzalez-Soriano J, Ferrer I, Santpere G , DeFelipe J 2009 Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer's disease. Journal of pathology, 219 41-51.

  • Knafo S, Alonso-Nanclares L, Gonzalez-Soriano J, Merino-Serrais P, Fernaud-Espinosa I, Ferrer I, DeFelipe J. 2009 Widespread changes in dendritic spines in a model of Alzheimer's disease. Cereb Cortex, 19 586-92.

  • Latasa MJ, Cisneros E,, Frade JM 2009 Cell cycle control of Notch signaling and the functional regionalization of the neuroepithelium during vertebrate neurogenesis. Int. J. Dev. Biol. 53: 895-908.

  • López-Ariztegui N, Arévalo MA, de Ceballos ML, Grandas F. 2009 Central Levodopa Influx and the Clinical Motor Response to Levodopa in Patients With Parkinson Disease Complicated With Motor Fluctuations and Dyskinesias. Clin Neuropharmacol, 32 321-5.

  • Llorens-Martín M, Torres-Alemán I, Trejo JL. Mechanisms mediating brain plasticity: IGF1 and adult hippocampal neurogenesis. Neuroscientist, 15 134-48.

  • Llorente R, Gallardo ML, Berzal AL, Prada C, García-Segura LM, Viveros MP 2009 Early maternal deprivation in rats induces gender-dependent effects on developing hippocampal and cerebellar cells. Int J Dev Neurosci, 27 233-41.

  • Perea, Gertrudis; Navarrete, Marta; Araque, Alfonso Tripartite synapses: astrocytes process and control synaptic information. Trends neuroscience, 32 421-31.

  • Pérez-Escudero, A., Rivera-Alba, M. and de Polavieja G. G. 2009. Structure of deviations from optimality in biological systems, PNAS 106, 20544-20549.

  • Merchán-Pérez A, Rodríguez JR, Ribak CE, DeFelipe J. 2009 Proximity of excitatory and inhibitory axon terminals adjacent to pyramidal cell bodies provides a putative basis for nonsynaptic interactions. Proc Natl Acad Sci U S A. 16;106:9878-83

  • Merchán-Pérez A, Rodríguez JR, Alonso-Nanclares L, Schertel A, Defelipe J. 2009 Counting Synapses Using FIB/SEM Microscopy: A True Revolution for Ultrastructural Volume Reconstruction. Front Neuroanat.;3:18.

  • Roberts AC, Díez-García J, Rodriguiz RM, López IP, Luján R, Martínez-Turrillas R, Picó E, Henson MA, Bernardo DR, Jarrett TM, Clendeninn DJ, López-Mascaraque L, Feng G, Lo DC, Wesseling JF, Wetsel WC, Philpot BD, Pérez-Otaño I. 2009 Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. Neuron 63 342-56.

  • Román-Trufero M, Méndez-Gómez HR, Pérez C, Koseki H, Vicario-Abejón, C, Vidal, M 2009 Maintenance of undifferentiated state and self-renewal of embryonic neural stem cells by Polycomb protein Ring1B. Stem Cells 27, 1559-1570.

  • Ruiz JM, Rodríguez J, Bovolenta P Growth and Differentiation of the Retina and the Optic Tectum in the Medaka Fish Requires olSfrp5. Developmental neurobiology, 69 617-32 .

  • Sánchez-Blazquez, Pilar; Rodríguez-Muñoz, Maria; de la Torre-Madrid, Elena; Garzon, Javier 2009 Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell signal, 21 1444-54.

  • Sánchez-Blázquez P, Rodríguez-Muñoz M, De la Torre-MadridE, Vicente-Sánchez A, Martín-AznarB, Garzón J. 2009 A study of the signalling proteins regulated by G protein-coupled receptors. Eur. J. Psychiatry 23S: 56-62

  • Sahota, V., Grau, B., Mansilla, A. and Ferrús, A. 2009 Troponin I and Tropomyosin regulate chromosomal stability and cell polarity. J. Cell Sci. 122, 2623-2631.

  • Sánchez-CamachoC.; Bovolenta, P. 2009 Emerging mechanisms in morphogen-mediated axon guidance. Bioessays, 31 1013-25.

  • Tan O, Fadiel A, Chang A, Demir N, Jeffrey R, Horvath T, García-Segura LM, Naftolin F 2009 Estrogens regulate posttranslational modification of neural cell adhesion molecule during the estrogen-induced gonadotropin surge. Endocrinology, 150 2783-90.

  • Valbuena A , Oroz J , Hervas R , Vera AM, Rodríguez D, Menendez, Sulkowska JI, Cieplak M, Carrion-Vazquez M. 2009 On the remarkable mechanostability of scaffoldins and the mechanical clamp motif. Proceedings of the National Academy of Sciences of The United States of America, 106  13791-6.

  • Varea O, Garrido JJ, Dopazo A, Mendez P, García-Segura LM, Wandosell F. 2009 Estradiol activates beta-catenin dependent transcription in neurons. PLoS ONE. 4:e5153.

  • Vergano-Vera E, Mendez-Gomez , Hurtado-Chong A, Cigudosa JC , Vicario-Abejo . 2009 Fibroblast growth factor-2 increases the expression of neurogenic genes and promotes the migration and differentiation of neurons derived from transplanted neural stem/progenitor cells. Neuroscience, 162: 39-54.

  • Viveros MP, Llorente R, López-Gallardo M, Suarez J, Bermúdez-Silva F, De la Fuente M, Rodríguez de Fonseca F, García-Segura LM. 2009 Sex-dependent alterations in response to maternal deprivation in rats. Psychoneuroendocrinology, 34S1 S217-S226.

  • Yague JG, Azcoitia I, Defelipe J, García-Segura LM, Muñoz A. 2009 Aromatase expression in the normal and epileptic human hippocampus. Brain Res. PubMed PMID: 19815003.

  • Yague JG, García-Segura LM , Azcoitia I 2009 Selective transcriptional regulation of aromatase gene by vitamin D, dexamethasone, and mifepristone in human glioma cells. Endocrine, 35 252-61.

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