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Departamentos > Neurobiología Molecular, Celular y del Desarrollo > Análisis Genético de la Regulación Sináptica y Muscular > Publicaciones

Investigación Personal Publicaciones Otros


Publicaciones de Alberto Ferrús:

  • 67.- MANSILLA, A.; MARTÍN F.A.; MARTÍN, D. and FERRÚS, A. (2015) Ligand independent requirements of steroid receptors EcR and USP for cell survival. Cell Death and Diff. (in press).

  • 66.- MARTÍN-PEÑA, A.; ACEBES, A.; RODRÍGUEZ, J.R.; CHEVALIER, V.; CASAS-TINTO, S.; TRIPHAN, T.; STRAUSS, R.; and FERRÚS, A. (2014). Cell types and coincident synapses in the ellipsoid body of Drosophila. Eur. J. Neurosci. 39: 1586-1601.

  • 65.- ROMERO-POZUELO, J.; DASON, J.S.; MANSILLA, A.; BAÑOS-MATEOS, S.; SARDINA, J.L.; CHAVES-SANJUÁN, A.; JURADO-GÓMEZ, J.; SANTANA, E.; ATWOOD, H.L.; HERNÁNDEZ-HERNÁNDEZ, A.; SÁNCHEZ-BARRENA, M.J.; and FERRÚS, A. (2014). The guanine-exchange factor Ric8a binds the calcium sensor NCS-1 to regulate synapse number and probability of release. J. Cell Sci. 127: 4246-4259.

  • 64.- ACEBES, A.; DEVAUD, JM.; ARNÉS, M. and FERRÚS, A. (2012) Central adaptation to odorants depends on PI3K levels in local interneurons of the antennal lobe. J. Neurosci. 32: 417-422.

  • 63.- Dason, JS.; Romero-Pozuelo, J.; Atwood, HL.; and Ferrús, A. (2012) Multiple Roles for Frequenin/NCS-1 in Synaptic Function and Development. Mol. Neurobiol. 45: 388-402.

  • 62.- ACEBES, A.; MARTIN-PEÑA, A.; CHEVALIER, V. and FERRÚS, A. (2011) Synapse loss in olfactory local interneurons modifies perception. J. Neurosci. 31: 2734-2745.

  • 61.- GRADILLA*, AC.; MANSILLA*, A. and FERRÚS, A. (2011) Isoform-specific Regulation of a Steroid Hormone Nuclear Receptor by an E3 Ubiquitin Ligase in D. melanogaster. Genetics 189: 1-13.

  • 60.- PANKOTAI, T.; POPESCU, C.; MARTIN, D.; GRAU, B.; ZSINDLEY, N.; BODAI,L.; TORA, L.; FERRÚS, A.* and BOROS, I.* (2010) Genes of the ecdysone biosynthesis pathway are regulated by the dATAC histone acetyltransferase complex in Drosophila. Mol. Cell. Biol. 30: 4254-4266.

  • 59.- Cuesto, G. ; Enriquez-Barreto, L.; Caramés, C.; Cantarero, M. ; Gasull, X.; Sandi, C.; Ferrús, A.; Acebes*, A. and Morales*, M. (2011) PI3K activation controls synaptogenesis and spinogenesis in hippocampal neurons. J. Neurosci. 31: 2721-2733.

  • 58.- SAHOTA, V., GRAU, B., MANSILLA, A. and FERRÚS, A. (2009) Troponin I and Tropomyosin regulate chromosomal stability and cell polarity. J. Cell Sci. 122, 2623-2631.

  • 57.- GRAU, B., POPESCU, C., TORROJA, L., ORTUÑO-SAHAGÚN, D., BOROS, I. and FERRÚS, A. (2008) The transcriptional adaptor Ada3 of Drosophila is required for histone modification, position effect variegation and transcription. Mol. Cell. Biol. 28, 376-385.

  • 56.- ROMERO-POZUELO, J., DAWSON, J.S., ATWOOD, H.L., AND FERRÚS, A. (2007) Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology. Eur. J. Neurosci. 26, 2428-2443.

  • 55.- MARTÍN-PEÑA, A., ACEBES, A., RODRÍGUEZ, J.R., SORRIBES, A., DE POLAVIEJA, G.G., FERNÁNDEZ-FÚNEZ, P. AND FERRÚS, A. (2006) Age-independent synaptogenesis by phosphoinositide 3 kinase. J. Neurosci. 26, 10199-10208.

  • 54.- WINTHER, Å., ACEBES, A., and FERRÚS, A. (2006). Tachykinin-related peptides modulate odor perception and locomotion activity in Drosophila. Mol. Cell Neurosci. 31, 399-406.

  • 53.- MARÍN I., IGNASI-LUCAS J., GRADILLA AC., and FERRÚS, A. (2004) Parkin and relatives: the RBR family of ubiquitin ligases. Physiological Genomics. 17, 253-263.

  • 52.- MARÍN, MC., RODRIGUEZ, JR. and FERRÚS, A. (2004) Transcription of Drosophila Troponin I gene is regulated by two conserved, functionally identical, synergistic elements. Mol. Biol. Cell. 15, 1185-1196.

  • 51.- DEVAUD, JM., ACEBES, A., RAMASWAMI, M. and FERRÚS, A. (2003) Structural and functional changes in the olfactory pathway of adult Drosophila take place at a critical age. J. Neurobiol. 56, 13-23.

  • 50.- DEVAUD, JM., KEATON, J. and FERRÚS, A. (2003) Blocking sensory inputs to identified antennal glomeruli selectively modifies odorant perception in Drosophila. J. Neurobiol. 56, 1-12.

  • 49.- HÄMMERLE,B. and FERRÚS,A. (2003) Expression of enhancers is altered in Drosophila melanogaster hybrids. Evol. & Devel. 5, 221-230.

  • 48.- MARIN,I. and FERRÚS,A. (2002) Comparative genomics of the RBR family, including the Parkinson’s disease-related gene parkin and genes of the ariadne subfamily. Mol. Biol. Evol. 12, 2039-2050.

  • 47.- DEVAUD, JM., ACEBES, A. and FERRÚS, A. (2001) Odor exposure causes central adaptation and specific morphological changes in olfactory glomeruli in Drosophila. J. Neurosci. 21, 6274-6282.

  • 46.- ACEBES,A. and FERRÚS,A. (2001) Increasing the number of synapses modifies olfactory perception in Drosophila. J. Neurosci. 21, 6264-6273.

  • 45.- NAIMI,B., HARRISON,A., CUMMINS,M., NONGTHOMBA,U., CLARK,S., CANAL,I., FERRÚS,A. and SPARROW,J.C. (2001) A tropomyosin-2 mutation suppresses a troponin I myopathy in Drosophila. Mol. Biol. Cell 12, 1529-1539.

  • 44.- HERNÁNDEZ-HERNÁNDEZ,A. and FERRÚS,A. (2001) Prodos is a conserved transcriptional regulator that interacts with dTAFII16 in Drosophila. Mol. Cell Biol. 2, 614-623.

  • 43.- FERRÚS,A., ACEBES,A., MARÍN,M.C. and HERNÁNDEZ-HERNÁNDEZ,A. (2001) A genetic approach to detect muscle protein interactions in vivo. Trends in Cardiovasc. Med. 10, 293-298.

  • 42.- ACEBES,A. and FERRÚS,A. (2000) Molecular and dynamic features of axon collaterals and dendrites. Trends in Neurosci. 23, 557-565.

  • 41.- AGUILERA,M.; OLIVEROS,M.; MARTÍNEZ-PADRÓN,M.; BARBAS,J.A. and FERRÚS,A. (2000) Ariadne-1: A vital Drosophila gene is required in development and defines a new conserved family of RING finger proteins. Genetics 155, 1231-1244.

  • 40.- MORALES,M.; FERRÚS,A. and MARTÍNEZ-PADRÓN,M. (1999) Presynaptic calcium-channel currents in normal and csp mutant Drosophila peptidergic terminals. Eur. J. Neurosci. 11, 1-9.

  • 39.- KRONERT, W.A.; ACEBES,A.; FERRÚS,A. and BERNSTEIN,S.I. (1999) Specific Myosin Heavy Chain Mutations Suppress Troponin I Defects in Drosophila Muscles. J. Cell Biol. 144, 989-1000.

  • 38.- PRADO,A.; CANAL,I. and FERRÚS,A. (1999) The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function. Genetics 151, 163-175.

  • 37.- LLEVADOT,R.; MARQUÉS,G.; PRITCHARD,M.; ESTIVILL,X.; FERRÚS,A. and SCAMBLER,P. (1998) Cloning, chromosome mapping and expression analysis of the HIRA gene from Drosophila melanogaster. Biochem. Biophys. Res. Commun. 249, 486-491.

  • 36.- TORROJA,L.; ORTUÑO-SAHAGUN,D.; FERRÚS,A.; HÄMMERLE,B. and BARBAS,J.A. (1998) scully, an essential gene of Drosophila, is homologous to mammalian mitochondrial type II L-3-hydroxyacyl-CoA dehydrogenase/amyloid-ƒÒpeptide-binding protein. J. Cell Biol. 141, 1009-1017.

  • 35.- CANAL.I.; ACEBES,A. and FERRÚS,A. (1998) Single neuron mosaics of the Drosophila gigas mutant project beyond normal targets and modify behavior. J. Neurosci. 18, 999-1008.

  • 34.- ANGAUT-PETIT,D.; TOTH,P.; ROGERO,O.; FAILLE,L.; TEJEDOR,F.J. and FERRÚS, A. (1998) Enhanced neurotransmitter release is associated with reduction of neuronal branching in a Drosophila mutant overexpressing frequenin. Eur. J. Neurosci. 10, 423-434.

  • 33.- MARTÍNEZ-PADRÓN, M. and FERRÚS, A. (1997) Patch-clamp recordings from Drosophila presynaptic terminals. In: "Cellular and Molecular Procedures in Developmental Biology". (F. De Pablo, A. Ferrús and C. Stern volume eds.) Series: Current Topics in Developmental Biology. (R. Petersen and J. Schatten, series eds.) Academic Press.

  • 32.- MARTÍNEZ-PADRÓN, M. and FERRÚS, A. (1997) Presynaptic recordings from Drosophila: Correlation of macroscopic and single-channel K+ currents. J. Neurosci. 17, 3412-3424.

  • 31.- PRADO,A.; CANAL,I.; BARBAS,J.A.; MOLLOY,J. and FERRÚS,A. (1995) Functional recovery of troponin I in a Drosophila heldup mutant after a second site mutation. Mol. Biol. Cell 6, 1433-1441.

  • 30.- FERRÚS,A. and CANAL, I. (1994) The Behaving Brain of a Fly. Trends in Neurosciences. 17, 479-486.

  • 29.- CANAL,I.; FARIÑAS,I; GHO,M. and FERRÚS,A. (1994) The presynaptic cell determines the number of synapses in the Drosophila optic ganglia. Eur. J. Neurosci. 6, 1423-1431.

  • 28.- BOURRET-POULAIN,C.; FERRÚS,A. and MALLART,A. (1994) Modulation of type A K+ current in Drosophila larval muscle by internal Ca++; effects of the overexpression of frequenin. Eur. J. Physiol. 427, 71-79.

  • 27.- PONGS,O.; LINDEMEIER,J.; ZHU,X.R.; THEIL,T.; ENGELKAMP,D.; KRAH-JENTGENS,I.; LAMBRECHT,H.G.; KOCH,K.W.; SCHWEMER,J.; RIVOSECCHI,R.; MALLART,A.; GALCERAN,J.; CANAL,I., BARBAS,J. and FERRÚS,A. (1993) Frequenin - A novel calcium binding protein that modulates synaptic efficacy in the Drosophila nervous system. Neuron 11, 15-28.

  • 26.- ANGAUT-PETIT,D.; FERRÚS,A and FAILLE,L. (1993) Plasticity of motor nerve terminals in Drosophila T(X;Y)V7 mutant. Neurosci. Lett. 153, 227-231.

  • 25.- BARBAS,J.A.; GALCERAN,J.; TORROJA,L.; PRADO,A. and FERRÚS,A. (1993) Abnormal muscle development in the heldup3 mutant of Drosophila is caused by a splicing defect on selected troponin I isoforms. Mol. Cell. Biol. 13, 1433-1439.

  • 24.- MALLART,A.; ANGAUT PETIT,D.; BOURRET POULAIN,C. and FERRÚS,A. (1991) Nerve terminal excitability and neuromuscular transmission in T(X;Y)V7 and Shaker mutants of Drosophila melanogaster. J. of Neurogenet. 7, 75-84.

  • 23.- BARBAS,J.A.; GALCERAN,J.; KRAH JENTGENS,I.; de la POMPA,J.L.; CANAL,I.; PONGS,O. and FERRÚS,A. (1991) Troponin I is encoded in the haplolethal region of the Shaker gene complex of Drosophila. Genes and Devel. 5, 132 140.

  • 22.- LICHTINGHAGEN,R.; STOCKER,M.; WITTKA,R.; BOHEIM,G.; STÜHMER,W.; FERRÚS,A. and PONGS,O. (1990) Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster. EMBO J. 9, 4399-4407.

  • 21.- STOCKER,M.; STÜHMER,W.; WITTKA,R.; WANG,X.; MÜLLER,R.; FERRÚS,A. and PONGS,O. (1990) Alternative Shaker transcripts express either rapidly inactivating or non inactivating K channels. Proc. Natl. Acad. Sci. USA. 87, 8903-8909.

  • 20.- FERRÚS,A.; LLAMAZARES,S.; DE LA POMPA,J.L., TANOUYE,M.A. and PONGS,O. (1990) Genetic analysis of the Shaker gene complex of Drosophila melanogaster. Genetics 125, 383 398.

  • 19.- ORGAD,S.; LLAMAZARES,S.; DUDAI.Y. and FERRÚS,A. (1989) The Drosophila mutant tetanic interacts with a gene complex including the structural locus of potassium channels and shows altered dephosphorylation and learning. Eur. J. of Neurosci. 1, 367 373.

  • 18.- BARBAS,J.A.; RUBIO,N.; PEDROSO,E.; PONGS,O. and FERRÚS,A. (1989) Antibodies against Drosophila potassium channels identify membrane proteins across species. Mol. Brain Res. 5, 171 176.

  • 17.- de la POMPA,J.L.; García,J. and FERRÚS,A. (1989) Genetic analysis of muscle development of Drosophila melanogaster. Dev. Biol. 131, 439 454.

  • 16.- GISSELMAN,G.; SEWING,S.; MADSEN,B.W.; MALLART,A.; ANGAUT PETIT,D.; MÜLLER HOLTKAMP,F.; FERRÚS,A. and PONGS,O. (1989) The interference of truncated with normal potassium channel subunits leads to abnormal behaviour in transgenic Drosophila melanogaster. EMBO J. 8, 2359 2364.

  • 15.- PONGS,O.; KECSKEMETHY,N.; MULLER,R.; KRAH JENTGENS,I.; BAUMANN,A.; KILTZ,H.H.; CANAL,I.; LLAMAZARES,S. and FERRÚS,A. (1988) Shaker encodes a family of putative channel proteins in the nervous system of Drosophila. EMBO J. 7, 1087 1096.

  • 14.- BAUMANN,A.; KRAH JENTGENS,I.; MULLER,R.; MULLER HOLTKAMP,F.; SEIDEL,R.; KECSKEMETHY,N.; CASAL,J.; FERRÚS,A. and PONGS,O. (1987) Molecular organization of the maternal effect region of the Shaker complex of Drosophila: Characterization of an Ia channel transcript with homology to vertebrate sodium channel. EMBO J. 6, 3419 3429.

  • 13.- CANAL,I. and FERRÚS,A. (1987) The expression of Ultrabithorax during development of the nervous system of Drosophila. J. of Neurogenet. 4, 161 177.

  • 12.- CANAL,I. and FERRÚS,A. (1986) The pattern of early neuronal differentiation in D. melanogaster. J. of Neurogenet. 3, 293 319.

  • 11.- TANOUYE,M.A. and FERRÚS,A. (1985) Action potentials in normal and Shaker mutant Drosophila. J. of Neurogenet. 2, 253 271.

  • 10.- PAGES,M.; JIMENEZ,F.; FERRÚS,A.; PERALTA,E.; RAMIREZ,G. and GELPI,E. (1983) Enkephalin like immunoreactivity in D. melanogaster. Neuropeptides 4, 87 98.

  • 9.- FUJITA,S.C.; ZIPURSKY,S.L.; BENZER,S.; FERRÚS,A. and SHOTWELL,S.L. (1982) Monoclonal antibodies against the Drosophila nervous system. Proc. Natl. Acad. Sci. USA. 79, 7929 7933.

  • 8.- TANOUYE,M.A.; FERRÚS,A. and FUJITA,S.C. (1981) Abnormal action potentials associated with the Shaker complex locus of Drosophila. Proc. Natl. Acad. Sci. USA. 78, 6548 6552.

  • 7.- KOTO,M.; TANOUYE,M.A.; FERRÚS,A.; THOMAS,J.B. and WYMANN,R.J. (1981) The morphology of the cervical giant fiber neuron of Drosophila. Brain Res. 221, 213 217.

  • 6.- FERRÚS,A. and KANKEL,D.R. (1981) Cell lineage relationships in D. melanogaster. The relationships of cuticular to internal tissues. Dev. Biol. 85, 485 504.

  • 5.- FERRÚS, A. (1979) Cell functions in morphogenesis. A clonal analysis of new morphogenetic mutants in D. melanogaster. Dev. Biol. 68, 16 28.

  • 4.- FERRÚS,A. and García BELLIDO,A. (1977) Minute mosaics caused by early chromosome loss. Wilh. Roux. Arch. 183, 337 349.

  • 3.- FERRÚS,A. and García BELLIDO,A. (1976) Morphogenetic mutants detected in mitotic recombination clones. Nature 260,425.

  • 2.- García BELLIDO,A. and FERRÚS,A. (1976) Gynandromorph fate map of the wing disk compartments in D. melanogaster. Wilh. Roux. Arch. 178, 337 340.

  • 1.- FERRÚS,A. (1975) Parameters of mitotic recombination in Minute mutants of D. melanogaster. Genetics 79, 589 599.

Publicaciones de Sergio Casas Tintó:


  • Portela M, Segura-Collar B, Argudo I, Sáiz A, Gargini R, Sánchez-Gómez P, Casas-Tintó S. Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking. Glia. 2019 Feb;67(2):404-417. doi: 10.1002/glia.23551.

  • Mansilla A, Jordán-Álvarez S, Santana E, Jarabo P, Casas-Tintó S, Ferrús A. Molecular mechanisms that change synapse number. J Neurogenet. 2018 Sep;32(3):155-170. doi: 10.1080/01677063.2018.1506781.


  • Lolo FN, Rius C, Casas-Tintó S. Elimination of classically-activated macrophages in tumor-conditioned medium by alternatively-activated macrophages.Biol Open. 2017 Dec 15;6(12):1897-1903. doi: 10.1242/bio.027300.

  • Arnés M, Casas-Tintó S, Malmendal A, Ferrús A. Amyloid β42 peptide is toxic to non-neural cells in Drosophila yielding a characteristic metabolite profile and the effect can be suppressed by PI3K.Biol Open. 2017 Nov 15;6(11):1664-1671. doi: 10.1242/bio.029991.

  • Santana E, Casas-Tintó S. Orb2 as modulator of Brat and their role at the neuromuscular junction. J Neurogenet. 2017 Dec;31(4):181-188. doi: 10.1080/01677063.2017.1393539. Epub 2017 Nov 6.

  • Jordán S., Santana E., Acebes A., Casas-Tintó S. and Ferrús A. The equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila. PLoS ONE. Sept 11;12(9).

  • Arnés M. and Casas-Tintó S. Aberrant Wnt signaling: a special focus in CNS diseases. J Neurogenet. Jun 21:1-7.

  • Casas-Tintó S*, Arnés M and Ferrús A. Drosophila enhancer-Gal4 lines show ectopic expression during development. Royal Society Open Science. Mar 29; 4(3):170039. *corresponding author


  • Casas-Tintó S, Maraver A, Serrano M, Ferrús A. Troponin-I enhances and is required for oncogenic overgrowth. Oncotarget. 2016 Jul 15.

  • Hervás R, Li L, Majumdar A, Fernández-Ramírez Mdel C, Unruh JR, Slaughter BD, Galera-Prat A, Santana E, Suzuki M, Nagai Y, Bruix M, Casas-Tintó S, Menéndez M, Laurents DV, Si K, Carrión-Vázquez M. Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation. PLoS Biol. 2016 Jan 26;14(1).


  • Zhang C, Casas-Tintó S, Li G, Lin N, Chung M, Moreno E, Moberg KH, Zhou L. An intergenic regulatory region mediates Drosophila Myc-induced apoptosis and blocks tissue hyperplasia. Oncogene. Apr 30;34(18):2412.

  • Panda D, Gold B, Tartell MA, Rausch K, Casas-Tintó S, Cherry S. The transcription factor FoxK participates with Nup98 to regulate antiviral gene expression. MBio. Apr 7;6(2). pii: e02509-14.

  • Casas-Tintó S*, Lolo, FN and Moreno*, E. dTyrosil-tRNA synthetase acts as a chemo-attractant for haemocytes during cell competition in Drosophila melanogaster. Nature Comm. 2015 Dec 11;6:10022. (*co-corresponding author).


  • Martín-Peña A, Acebes A, Rodriguez JR, Chevalier V, Casas-Tintó S, Triphan T, Strauss R, Ferrús A. Cell types and coincident synapses in the ellipsoid body of Drosophila. Eur J Neurosci. 39(10):1586-601.


  • Lolo, FN*, Casas Tintó, S* and Moreno, E. Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes. Cell Reports. 2(3): 526-39. (* co-first author).


  • Casas-Tintó S, Zhang Y, Sánchez-García J, Gómez-Velázquez M, Rincón-Limas DE, Fernández-Fúnez P. The ER stress factor XBP1s prevents Amyloid-ß neurotoxicity. Hum. Mol. Gen. 20(11): 2144-60.

  • Casas-Tintó, S and Moreno E. Mechanisms that define winners and losers of cell-competition- Sparc and fwe are markers of cell competition. Exp. Medicine. 9: 1351-57.


  • Portela M*, Casas-Tinto S*, Rhiner C*, López-Gay JM, Domínguez O, Soldini D, Moreno E. Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition. Dev. Cell. 19(4): 562-73. (* co-first author).

  • Rhiner C, López-Gay JM, Soldini D, Casas-Tinto S, Martín FA, Lombardía L, Moreno E. Flower forms an extracellular code that reveals the fitness to its neighbors in Drosophila. Dev. Cell. 18(6): 985-98.


  • Casas-Tintó S*, Gómez-Velázquez M, Granadino B, Fernández-Fúnez P*. FoxK mediates TGF-beta signaling during midgut differentiation in flies. J Cell Biol. 15;183(6):1049-60. (*corresponding author).


  • Casas-Tintó S, Marr MT 2nd, Andreu P, Puig O. Characterization of the Drosophila insulin receptor promoter. Biochem Biophys Acta. 69(4):236-43.

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